National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Infection and Immunity, Children's Hospital of Chongqing Medical University, Chongqing, 400014, People's Republic of China.
Department of Pediatric Intensive Care Unit, Taihe Hospital, Hubei University of Medicine, Hubei, China.
Hepatol Int. 2020 Jul;14(4):503-512. doi: 10.1007/s12072-020-10055-9. Epub 2020 May 29.
The risk of occult HBV infection (OBI) in children whose mothers are HBV carriers has received more widespread attention, but there were few reports to focus on the children with HBsAg-positive parents. In this study, we aimed to investigate the prevalence of OBI in immunized children with HBsAg-positive parents.
HBV-vaccinated Chinese hospitalized children with HBsAg-positive parents were analyzed in our investigation. Eligible subjects were tested using a standard nested PCR for all HBV genes, and analyzed by direct sequencing.
There were 327 HBsAg-negative children included in the study out of about 9800 involved HBV-vaccinated hospitalized children. The positive rate of OBI was 3.1% (10/327) in the eligible children and 14.1% (46/327) with HBV DNA detectable. No significant differences were found between one and at least two regions positive groups (p > 0.05). The proportions of HBV DNA detectable in children with HBV father-carriers and mother-carriers were similar. The risk factors for HBV DNA-positive children could be male, anti-HBs levels, and anti-HBc positive.
There are 3.1% of OBIs and 14.1% of suspected OBI in vaccinated children with HBsAg-positive parents. The potential risk of suspected OBI in children with HBsAg-positive father should not be ignored. Anti-HBc positivity may be a useful seromarker for suspected OBI screening in vaccinated children. To prevent HBV breakthrough infection, accurate and convenient method is needed to detect OBI timely and exhaustively.
HBV 携带者母亲所生子女的隐匿性 HBV 感染（OBI）风险受到了更广泛的关注，但很少有报道专门针对 HBsAg 阳性父母的子女。本研究旨在调查 HBsAg 阳性父母的免疫儿童中 OBI 的流行率。
我们对 HBsAg 阳性父母的 HBV 疫苗接种住院儿童进行了分析。对符合条件的受试者进行了所有 HBV 基因的标准巢式 PCR 检测，并进行了直接测序分析。
在约 9800 例接受 HBV 疫苗接种的住院儿童中，本研究纳入了 327 例 HBsAg 阴性儿童。在符合条件的儿童中，OBI 的阳性率为 3.1%（10/327），HBV DNA 可检测的阳性率为 14.1%（46/327）。一个和至少两个区域阳性组之间没有发现显著差异（p>0.05）。HBV 父亲携带者和母亲携带者的儿童中 HBV DNA 可检测的比例相似。HBV DNA 阳性儿童的危险因素可能是男性、抗-HBs 水平和抗-HBc 阳性。
HBsAg 阳性父母的疫苗接种儿童中存在 3.1%的 OBI 和 14.1%的疑似 OBI。不应忽视 HBsAg 阳性父亲的儿童中疑似 OBI 的潜在风险。抗-HBc 阳性可能是疫苗接种儿童疑似 OBI 筛查的有用血清标志物。为了防止 HBV 突破感染，需要及时、全面地检测 OBI，使用准确、便捷的方法。
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