Block C H, Santos R A, Brosnihan K B, Ferrario C M
Research Institute of the Cleveland Clinic Foundation, OH 44195-5070.
Peptides. 1988 Nov-Dec;9(6):1395-401. doi: 10.1016/0196-9781(88)90208-2.
Recent findings by this group have led us to reconsider the view that amino (N-) terminal fragments of angiotensin (Ang) II are inactive degradation products of renin-angiotensin system. To further examine this possibility, an antibody to Ang-(1-7), the N-terminal heptapeptide, was produced to demonstrate the neuroanatomical distribution of the rat brain. Ang-(1-7)-immunoreactivity was found in paraventricular, supraoptic, and suprachiasmatic nuclei, bed nucleus of the stria terminalis, substantia innominata, median eminence, and neurohypophysis. This distribution of Ang-(1-7) in the rat forebrain, together with our previous demonstrations of vasopressin secretion in response to this peptide, suggest that Ang-(1-7) functions as a neuromodulator.
血管紧张素（Ang）II的氨基（N-）末端片段是肾素-血管紧张素系统的无活性降解产物。为了进一步研究这种可能性，制备了一种针对N末端七肽Ang-(1-7)的抗体，以显示大鼠脑中的神经解剖分布。在室旁核、视上核、视交叉上核、终纹床核、无名质、正中隆起和神经垂体中发现了Ang-(1-7)免疫反应性。Ang-(1-7)在大鼠前脑的这种分布，以及我们之前证明的该肽可引起血管加压素分泌，表明Ang-(1-7)起着神经调质的作用。
