Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
Digestive Disease Center, Showa Inan General Hospital, Komagane, Japan.
Pediatr Int. 2020 Nov;62(11):1269-1274. doi: 10.1111/ped.14324. Epub 2020 Nov 4.
Although the prevalence of gastroesophageal reflux disease (GERD) has been increasing in Japan, little is known about the prevalence and severity of GERD in pediatric patients. This study compared the prevalence and severity of endoscopically proven GERD in pediatric patients seen at an endoscopy center in Japan over a 15-year period.
This was a retrospective chart review of Japanese children aged 5-18 years undergoing esophagogastroduodenoscopy for upper gastrointestinal symptoms or anemia between 2005 and 2019. The prevalence and severity of reflux esophagitis and endoscopic Barrett's esophagus were compared between the periods 2005-2012 and 2013-2019.
A total of 564 patients were evaluated: 315 from 2005 to 2012 (mean ± SD) age 13.8 ± 3.0 (range, 5-18 years; 147 boys; and 249 from 2013 to 2019 (mean ± SD) 14.7 ± 2.8 (range, 5-18) years; 108 boys. Demographics and clinical features were similar between the two groups. The proportion with erosive esophagitis or endoscopic Barrett's esophagus increased significantly between the two periods (9.8% to 18.1% for GERD, P = 0.0045 and 2.5% to 9.6% for Barrett's esophagus, P = 0.0003). The proportion of GERD patients with endoscopic Barrett's esophagus also significantly increased between the two periods (24/45 [53.3%]) vs (8/31 [25.8%]), P = 0.017].
The prevalence and severity of endoscopically proven GERDs has significantly increased over the past 15 years at an endoscopy center in Japan. Detailed population-based studies are needed to assess whether this is occurring throughout Japan.
尽管胃食管反流病（GERD）在日本的患病率一直在上升，但对于儿科患者中 GERD 的患病率和严重程度知之甚少。本研究比较了日本内镜中心 15 年来儿科患者内镜证实的 GERD 的患病率和严重程度。
这是一项回顾性图表审查，纳入 2005 年至 2019 年间因上消化道症状或贫血接受食管胃十二指肠镜检查的 5-18 岁日本儿童。比较了 2005-2012 年和 2013-2019 年期间反流性食管炎和内镜 Barrett 食管的患病率和严重程度。
共评估了 564 例患者：2005 年至 2012 年（平均±标准差）年龄 13.8±3.0（范围，5-18 岁；147 例男性；2013 年至 2019 年（平均±标准差）年龄 14.7±2.8（范围，5-18 岁）；108 例男性。两组患者的人口统计学和临床特征相似。两个时期之间，有糜烂性食管炎或内镜 Barrett 食管的患者比例显著增加（GERD 从 9.8%增加到 18.1%，P=0.0045，Barrett 食管从 2.5%增加到 9.6%，P=0.0003）。两个时期之间，内镜 Barrett 食管的 GERD 患者比例也显著增加（45 例中有 24 例[53.3%]）vs（31 例中有 8 例[25.8%]），P=0.017）。
在过去的 15 年里，日本内镜中心内镜证实的 GERD 的患病率和严重程度显著增加。需要进行详细的基于人群的研究，以评估这种情况是否在日本各地都存在。
