Exercise & Sport Nutrition Lab, Department of Kinesiology and Sport Management, Texas A&M University, College Station, TX 77843, USA.
Nutrients. 2023 Jul 7;15(13):3073. doi: 10.3390/nu15133073.
Recent research supports previous contentions that encapsulating vitamins and minerals with liposomes help improve overall bioavailability. This study examined whether ingesting a liposomal multivitamin and mineral supplement (MVM) differentially affects the appearance and/or clearance of vitamins and minerals in the blood compared to a non-liposomal MVM supplement. In a double-blind, randomized, and counterbalanced manner, 34 healthy men and women fasted for 12 h. Then, they ingested a non-liposomal (NL) or liposomal (L) MVM supplement and a standardized snack. Venous blood samples were obtained at 0, 2, 4, and 6 h after MVM ingestion and analyzed for a panel of vitamins and minerals. Plasma levels of vitamins and minerals and mean changes from baseline with 95% confidence intervals (CIs) were analyzed using general linear model statistics with repeated measures. The observed values were also entered into pharmacokinetic analysis software and analyzed through univariate analysis of variance with repeated measure contrasts. The results revealed an overall treatment x time interaction effect among the vitamins and minerals evaluated ( = 0.051, ηp2 = 0.054, moderate effect). Differences between treatments were also observed in volume distribution area (vitamin E, iron), median residence time (vitamin E, iron), volume distribution area (iron), volume of distribution steady state (vitamin A, E, iron), clearance rates (vitamin A, E), elimination phase half-life (vitamin E, iron), distribution/absorption phase intercept (vitamin A), and distribution/absorption phase slope and rate (vitamin C, calcium). Vitamin volume distribution was lower with liposomal MVM ingestion than non-liposomal MVM sources, suggesting greater clearance and absorption since similar amounts of vitamins and minerals were ingested. These findings indicate that coating a MVM with liposomes affects individual nutrient pharmacokinetic profiles. Additional research should evaluate how long-term supplementation of liposomal MVM supplements may affect vitamin and mineral status, nutrient function, and/or health outcomes.
最近的研究支持了先前的论点，即使用脂质体包裹维生素和矿物质有助于提高整体生物利用度。本研究旨在检验与非脂质体 MVM 补充剂相比，摄入脂质体多种维生素和矿物质补充剂（MVM）是否会对血液中维生素和矿物质的外观和/或清除产生不同的影响。在一项双盲、随机和对照的研究中，34 名健康的男性和女性禁食 12 小时。然后，他们摄入非脂质体（NL）或脂质体（L）MVM 补充剂和标准化的零食。在 MVM 摄入后 0、2、4 和 6 小时采集静脉血样，并分析一系列维生素和矿物质。使用重复测量的一般线性模型统计分析来分析血浆维生素和矿物质水平以及与基线相比的平均变化，并使用 95%置信区间（CI）。观察值也被输入药代动力学分析软件，并通过具有重复测量对比的单变量方差分析进行分析。结果显示，在所评估的维生素和矿物质中，存在总体处理 x 时间的交互效应（=0.051，ηp2=0.054，中等效应）。在处理之间也观察到了差异，包括分布容积面积（维生素 E、铁）、中位居留时间（维生素 E、铁）、分布容积面积（铁）、分布稳态容积（维生素 A、E、铁）、清除率（维生素 A、E）、消除相半衰期（维生素 E、铁）、分布/吸收相截距（维生素 A）以及分布/吸收相斜率和速率（维生素 C、钙）。与非脂质体 MVM 来源相比，脂质体 MVM 摄入后维生素的体积分布较低，这表明清除和吸收速度更快，因为摄入了相似量的维生素和矿物质。这些发现表明，用脂质体包裹 MVM 会影响个体营养素的药代动力学特征。应开展更多研究来评估长期补充脂质体 MVM 补充剂如何影响维生素和矿物质状态、营养素功能和/或健康结果。
