Department of Urology, The Second Hospital of TianJin Medical University, TianJin Institute of Urology, Tianjin, 300211, China; Department of Urology, Lu'an Affiliated Hospital of Anhui Medical University, 237000, Anhui, China.
Department of Urology, The Second Hospital of TianJin Medical University, TianJin Institute of Urology, Tianjin, 300211, China; Department of Anorectal Surgery, Tianjin Union Medical Center, 300121, Tianjin, China.
Cancer Lett. 2020 Sep 1;487:45-52. doi: 10.1016/j.canlet.2020.05.019. Epub 2020 May 29.
With advances in modern medicine, diverse tumor therapies have been developed. However, because of a lack of effective methods, the delivery of drugs or micromolecules in the human body has many limitations. Biomaterials are natural or synthetic functional materials that are prone to contact or interact with living systems. Therefore, the application of biomaterials provides innovative anti-tumor strategies, especially in tumor targeting, chemotherapy sensitization, tumor immunotherapy. The combination of biomaterials and drugs provides a promising strategy to overcome the biological barriers of drug delivery. Nanomaterials can target specific tumor sites to enhance the efficiency of tumor therapies and decrease the toxicity of drug through passive targeting, active targeting and direct targeting. Additionally, biomaterials can be used to enhance the sensitivity of tumor cells to chemotherapy drugs. Furthermore, modifiable biomaterials can induce effective anti-tumor immune response. Currently, the developmental trend of biomaterial for drug delivery is motivated by the combination and diversification of different therapies. With interdisciplinary development, a variety of anti-tumor strategies will emerge in an endless stream to bring great hope for tumor therapy. In this review, we will discuss the anti-tumor strategies based on nanoparticles and injectable scaffolds.
随着现代医学的进步，已经开发出了多种肿瘤治疗方法。然而，由于缺乏有效的方法，药物或微分子在人体内的输送存在许多限制。生物材料是易于与生命系统接触或相互作用的天然或合成功能材料。因此，生物材料的应用提供了创新的抗肿瘤策略，特别是在肿瘤靶向、化疗增敏、肿瘤免疫治疗方面。生物材料与药物的结合为克服药物输送的生物学障碍提供了有前途的策略。纳米材料可以靶向特定的肿瘤部位，通过被动靶向、主动靶向和直接靶向来提高肿瘤治疗的效率并降低药物的毒性。此外，生物材料可用于增强肿瘤细胞对化疗药物的敏感性。此外，可修饰的生物材料可以诱导有效的抗肿瘤免疫反应。目前，基于纳米粒子和可注射支架的药物输送生物材料的发展趋势是由不同治疗方法的结合和多样化所驱动的。随着学科的发展，各种抗肿瘤策略将层出不穷，为肿瘤治疗带来了巨大的希望。在这篇综述中，我们将讨论基于纳米粒子和可注射支架的抗肿瘤策略。
