Chabrillac Emilien, Tourrette Audrey, Habib Michel, Blanchy Marilys, Des Courtils Céline, D'Andréa Grégoire, Lavalle Philippe, Dupret-Bories Agnès
Department of Surgery, University Cancer Institute of Toulouse, Toulouse, France.
CIRIMAT, Université Toulouse 3 Paul Sabatier, Toulouse INP, CNRS, Université de Toulouse, Toulouse, France.
Head Neck. 2025 Jul;47(7):2048-2057. doi: 10.1002/hed.28175. Epub 2025 Apr 22.
PharyngoCutaneous Fistulae (PCF) represent a significant clinical challenge in otorhinolaryngology practice. The use of biomaterials could improve outcomes or even replace the use of a flap in pharyngolaryngeal surgery.
This systematic review included all studies evaluating the application of biomaterials for the prevention of PCF after pharyngeal surgery.
A total of 19 articles (12 clinical and 7 animal studies) were included. They assessed the use of a biomaterial to cover mucosal sutures (n = 15) or to replace a mucosal defect and guide secondary healing (n = 4). Most studies evaluated commercialized biomaterials (n = 11) rather than experimental devices (n = 5) or platelet-derived autologous medical devices (n = 4).
There are already strong arguments to support the use of several biomaterials to cover pharyngeal sutures in order to decrease the rate of PCF after TL or TPL. Replacing a pharyngeal mucosal defect by a biomaterial is currently a more elusive goal.
咽皮肤瘘（PCF）是耳鼻咽喉科临床实践中的一项重大挑战。生物材料的使用可能会改善治疗效果，甚至在咽喉手术中替代皮瓣的使用。
本系统评价纳入了所有评估生物材料在预防咽手术后PCF应用的研究。
共纳入19篇文章（12篇临床研究和7篇动物研究）。这些研究评估了使用生物材料覆盖黏膜缝线（n = 15）或替代黏膜缺损并引导二期愈合（n = 4）的情况。大多数研究评估的是商业化生物材料（n = 11），而非实验装置（n = 5）或血小板衍生的自体医疗装置（n = 4）。
已有充分论据支持使用多种生物材料覆盖咽缝线，以降低全喉或部分喉切除术后PCF的发生率。目前，用生物材料替代咽黏膜缺损仍是一个较难实现的目标。
