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Ψ网络:聚焦于CT图像上脑出血的边界区域。

Ψ-Net: Focusing on the border areas of intracerebral hemorrhage on CT images.

作者信息

Kuang Zhuo, Deng Xianbo, Yu Li, Wang Hongkui, Li Tiansong, Wang Shengwei

机构信息

School of Electronic Information and Communications, Huazhong University of Science and Technology, Wuhan, 430074, China.

Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

出版信息

Comput Methods Programs Biomed. 2020 Oct;194:105546. doi: 10.1016/j.cmpb.2020.105546. Epub 2020 May 14.

Abstract

BACKGROUND AND OBJECTIVE

The volume of the intracerebral hemorrhage (ICH) obtained from CT scans is essential for quantification and treatment planning. However,a fast and accurate volume acquisition brings great challenges. On the one hand, it is both time consuming and operator dependent for manual segmentation, which is the gold standard for volume estimation. On the other hand, low contrast to normal tissues, irregular shapes and distributions of the hemorrhage make the existing automatic segmentation methods hard to achieve satisfactory performance.

METHOD

To solve above problems, a CNN-based architecture is proposed in this work, consisting of a novel model, which is named as Ψ-Net and a multi-level training strategy. In the structure of Ψ-Net, a self-attention block and a contextual-attention block is designed to suppresses the irrelevant information and segment border areas of the hemorrhage more finely. Further, an multi-level training strategy is put forward to facilitate the training process. By adding the slice-level learning and a weighted loss, the multi-level training strategy effectively alleviates the problems of vanishing gradient and the class imbalance. The proposed training strategy could be applied to most of the segmentation networks, especially for complex models and on small datasets.

RESULTS

The proposed architecture is evaluated on a spontaneous ICH dataset and a traumatic ICH dataset. Compared to the previous works on the ICH sementation, the proposed architecture obtains the state-of-the-art performance(Dice of 0.950) on the spontaneous ICH, and comparable results(Dice of 0.895) with the best method on the traumatic ICH. On the other hand, the time consumption of the proposed architecture is much less than the previous methods on both training and inference. Morever, experiment results on various of models prove the universality of the multi-level training strategy.

CONCLUSIONS

This study proposed a novel CNN-based architecture, Ψ-Net with multi-level training strategy. It takes less time for training and achives superior performance than previous ICH segmentaion methods.

摘要

背景与目的

通过CT扫描获得的脑出血(ICH)体积对于量化和治疗规划至关重要。然而,快速准确地获取体积带来了巨大挑战。一方面,手动分割作为体积估计的金标准,既耗时又依赖操作人员。另一方面,出血与正常组织的对比度低、形状不规则以及分布情况使得现有的自动分割方法难以取得令人满意的性能。

方法

为了解决上述问题,本文提出了一种基于卷积神经网络(CNN)的架构,它由一个名为Ψ-Net的新型模型和一种多级训练策略组成。在Ψ-Net的结构中,设计了一个自注意力模块和一个上下文注意力模块,以抑制无关信息并更精细地分割出血的边界区域。此外,还提出了一种多级训练策略来促进训练过程。通过添加切片级学习和加权损失,多级训练策略有效地缓解了梯度消失和类别不平衡的问题。所提出的训练策略可应用于大多数分割网络,特别是对于复杂模型和小数据集。

结果

所提出的架构在自发性脑出血数据集和外伤性脑出血数据集上进行了评估。与先前关于脑出血分割的工作相比,所提出的架构在自发性脑出血上取得了最优性能(Dice系数为0.950),在外伤性脑出血上与最佳方法取得了相当的结果(Dice系数为0.895)。另一方面,所提出架构的训练和推理时间消耗远低于先前方法。此外,在各种模型上的实验结果证明了多级训练策略的通用性。

结论

本研究提出了一种基于CNN的新型架构Ψ-Net及其多级训练策略。与先前的脑出血分割方法相比,它训练时间更短且性能更优。

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