Yam Charmaine, Merlo Daniel, Stankovich Jim, Darby David, Gresle Melissa, Kalincik Tomas, Kilpatrick Trevor J, Lechner-Scott Jeanette, Taylor Bruce, Barnett Michael, Butzkueven Helmut, van der Walt Anneke
Department of Neurology, Box Hill Hospital, Melbourne, Australia.
Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Australia; Department of Neurology, Box Hill Hospital, Melbourne, Australia.
Mult Scler Relat Disord. 2020 Aug;43:102212. doi: 10.1016/j.msard.2020.102212. Epub 2020 May 25.
Monitoring and screening of cognitive function in the ambulatory setting requires simple, brief cognitive tests that are reproducible. MSReactor (MSR) is a web-based platform that screens psychomotor (processing) speed, attention and working memory using a game-like interface. The Processing Speed Test (PST) is a validated computerized version of the Symbol Digit Modalities test (SDMT) and component of the Multiple Sclerosis Performance Test (MSPT).
To determine the baseline and 6-month predictive correlations between the MSReactor computerised cognitive battery and the PST.
Prospectively enrolled relapsing-remitting multiple sclerosis (RRMS) patients completed the MSR and the PST during 6-monthly clinic visits. Pearson's product-moment coefficients with partial correlation adjustment were calculated between the PST and MSR reaction times for Simple reaction test (SRT), Choice reaction test (CRT) and One- back test (OBK).
379 RRMS patients from six tertiary MS centres in Australia were enrolled. The mean age was 40.4 years (SD 10.3) and median Expanded Disability Status Scale (EDSS) score was 1.5 (IQR 1.0 - 2.0). Most (66%) were on high efficacy disease-modifying treatment. Baseline PST scores correlated with the MSR reaction times: SRT (R=-0.40), CRT (R= -0.44) and OBK (R= -0.47), p <0.05. There was a moderate correlation between the first visit MSR and 6-month PST test for SRT (R= -0.37, p<0.001), CRT (R=-0.44, p < 0.001) and OBK (R= -0.43, p < 0.001) speed.
MSR-measured psychomotor speed, attention and working memory at baseline moderately correlates with baseline and 6-month PST; suggesting overlapping cognitive processes are being tested. Six-month test-retest reliability was acceptable for both tests.
在门诊环境中监测和筛查认知功能需要简单、简短且可重复的认知测试。MSReactor（MSR）是一个基于网络的平台，它使用类似游戏的界面来筛查心理运动（处理）速度、注意力和工作记忆。处理速度测试（PST）是符号数字模态测试（SDMT）的经过验证的计算机化版本，也是多发性硬化症性能测试（MSPT）的组成部分。
确定MSReactor计算机化认知测试组合与PST之间的基线及6个月预测相关性。
前瞻性纳入复发缓解型多发性硬化症（RRMS）患者，在每6个月的门诊就诊时完成MSR和PST测试。计算PST与MSR中简单反应测试（SRT）、选择反应测试（CRT）和单样本回溯测试（OBK）的反应时间之间的Pearson积矩系数，并进行偏相关调整。
来自澳大利亚六个三级MS中心的379例RRMS患者被纳入研究。平均年龄为40.4岁（标准差10.3），扩展残疾状态量表（EDSS）中位数评分为1.5（四分位间距1.0 - 2.0）。大多数（66%）患者正在接受高效疾病修饰治疗。基线PST分数与MSR反应时间相关：SRT（R = -0.40）、CRT（R = -0.44）和OBK（R = -0.47），p <0.05。首次就诊时的MSR与6个月后的PST测试在SRT（R = -0.37，p <0.001）、CRT（R = -0.44，p <0.001）和OBK（R = -0.43，p <0.001）速度方面存在中度相关性。
MSR测量的基线心理运动速度、注意力和工作记忆与基线及6个月后的PST中度相关；表明所测试的认知过程存在重叠。两种测试的6个月重测信度均可接受。
