Division of Infectious Diseases, Faculty of Medicine, Thammasat University, Khlong Nueng, Pathumthani, Thailand.
Int J Mycobacteriol. 2020 Jan-Mar;9(1):91-94. doi: 10.4103/ijmy.ijmy_182_19.
Mycobacterium scrofulaceum is an environmental mycobacterial species rarely reported to cause disseminated infection in adults. We report the case of a disseminated M. scrofulaceum infection in a 55-year-old nonhuman immunodeficiency virus-infected Thai man with anti-interferon-γ autoantibodies. The clinical signs of the infection improved after the induction regimen with amikacin, rifampicin, ethambutol, and clarithromycin, followed by the consolidation regimen with ethambutol, clarithromycin, and trimethoprim/sulfamethoxazole. Our review of previous reported cases of this infection indicates its association with immune deficiency, complex treatment, and a high rate of unfavorable outcomes.
瘰疬分枝杆菌是一种环境分枝杆菌种，很少有报道称其可导致成人播散性感染。我们报告了一例由抗干扰素-γ自身抗体引起的 55 岁非人类免疫缺陷病毒感染的泰国男性患者发生播散性瘰疬分枝杆菌感染的病例。在用阿米卡星、利福平、乙胺丁醇和克拉霉素进行诱导治疗后，患者的感染临床症状得到改善，随后用乙胺丁醇、克拉霉素和复方磺胺甲噁唑进行巩固治疗。我们对之前报道的此类感染病例进行了回顾，结果表明其与免疫缺陷、复杂的治疗以及不良结局发生率高有关。
