Department of Pediatrics and Adolescent Medicine, Ulm University Medical Centre, D-89075, Ulm, Germany.
Leukemia. 2020 Sep;34(9):2305-2316. doi: 10.1038/s41375-020-0886-x. Epub 2020 May 30.
The bone marrow is home to well-balanced normal hematopoiesis, but also the stage of leukemia's crime. Marrow adipose tissue (MAT) is a unique and versatile component of the bone marrow niche. While the importance of MAT for bone health has long been recognized, its complex role in hematopoiesis has only recently gained attention. In this review article we summarize recent conceptual advances in the field of MAT research and how these developments impact our understanding of MAT regulation of hematopoiesis. Elucidating routes of interaction and regulation between MAT and cells of the hematopoietic system are essential to pinpoint vulnerable processes resulting in malignant transformation. The concept of white adipose tissue contributing to cancer development and progression on the cellular, metabolic, and systemic level is generally accepted. The role of MAT in malignant hematopoiesis, however, is controversial. MAT is very sensitive to changes in the patient's metabolic status hampering a clear definition of its role in different clinical situations. Here, we discuss future directions for leukemia research in the context of metabolism-induced modifications of MAT and other adipose tissues and how this might impact on leukemia cell survival, proliferation, and antileukemic therapy.
骨髓是平衡正常造血的家园，但也是白血病犯罪的阶段。骨髓脂肪组织（MAT）是骨髓龛的独特且多功能组成部分。虽然 MAT 对骨骼健康的重要性早已被认识到，但它在造血中的复杂作用直到最近才引起关注。在这篇综述文章中，我们总结了 MAT 研究领域的最新概念进展，以及这些进展如何影响我们对 MAT 调节造血的理解。阐明 MAT 与造血系统细胞之间的相互作用和调节途径对于确定导致恶性转化的脆弱过程至关重要。白色脂肪组织有助于癌症在细胞、代谢和全身水平上发展和进展的概念已被普遍接受。然而，MAT 在恶性造血中的作用存在争议。MAT 对患者代谢状态的变化非常敏感，这阻碍了其在不同临床情况下的作用的明确定义。在这里，我们讨论了在代谢诱导的 MAT 和其他脂肪组织改变的背景下白血病研究的未来方向，以及这可能如何影响白血病细胞的存活、增殖和抗白血病治疗。
