Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Inflammatory Bowel Disease Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University; Shanghai Institute of Digestive Disease, 160# Pu Jian Ave, Shanghai, 200127, China.
Clin Rev Allergy Immunol. 2021 Apr;60(2):164-174. doi: 10.1007/s12016-020-08795-5.
Crohn's disease (CD) is a type of inflammatory bowel disease (IBD) and affects diverse segments of the entire gastrointestinal tract. Although the underlying causes of CD are not completely known, it is believed that disruption of the intestinal barrier and cell polarity may contribute to pathogenesis. The formation of the intestinal epithelial barrier, which is mainly regulated by cytoskeletal modulations, and apico-basal cell polarity are two major and mutually dependent features of the intestinal epithelial layer. As this layer serves as an important barrier between the external environment and the internal milieu, the defect can start an inflammatory cascade by failing to block the entrance of luminal pathogens and lead to CD. In this review, we highlight the factors and impact of intestinal barrier function and cell polarity in the natural history of CD. The discussion in the present review further strengthens the new challenge in facilitating the development of viable pharmacological targets.
克罗恩病（CD）是一种炎症性肠病（IBD），影响整个胃肠道的不同部位。虽然 CD 的根本原因尚不完全清楚，但据信肠道屏障和细胞极性的破坏可能有助于发病机制。肠道上皮屏障的形成主要受细胞骨架调节，顶端-基底细胞极性是肠道上皮层的两个主要且相互依赖的特征。由于该层作为外部环境和内部环境之间的重要屏障，其缺陷可通过未能阻止腔内容物病原体的进入而引发炎症级联反应，从而导致 CD。在这篇综述中，我们强调了肠道屏障功能和细胞极性在 CD 自然史中的作用和影响。本综述中的讨论进一步加强了促进可行的药理靶点发展的新挑战。
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