Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Curr Med Sci. 2020 Jun;40(3):518-522. doi: 10.1007/s11596-020-2204-2. Epub 2020 May 30.
Primary thyroid lymphoma (PTL) is an exceptionally rare and highly aggressive potentially curable malignant disease. We report three typical cases of PTL referred to our hospital. All three cases had long history of Hashimoto's thyroiditis, and presented with progressively enlarging neck mass. The first two cases were confirmed by surgical biopsy to be diffuse large B cell lymphoma, and received radiotherapy combined with chemotherapy, or received only chemotherapy. The third case was confirmed by core needle biopsy to be mucosa-associated lymphoid tissue lymphoma, and received radiotherapy. In summary, confirmation of PTL diagnosis is essential for further clinical decisions. Core biopsy should be one of the most important methods to make the diagnosis of PTL, while the use of fine needle aspiration cytology alone is still limited in diagnosing PTL.
原发性甲状腺淋巴瘤（PTL）是一种非常罕见且高度侵袭性的潜在可治愈的恶性疾病。我们报告了三例转诊至我院的 PTL 典型病例。这 3 例均有较长的桥本甲状腺炎病史，表现为逐渐增大的颈部肿块。前两例通过手术活检证实为弥漫性大 B 细胞淋巴瘤，接受了放化疗联合治疗，或仅接受了化疗。第三例通过核心针活检证实为黏膜相关淋巴组织淋巴瘤，接受了放疗。总之，PTL 的确诊对进一步的临床决策至关重要。核心活检应该是确诊 PTL 的最重要方法之一，而单独使用细针抽吸细胞学检查在诊断 PTL 方面仍然有限。
