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术前体重指数的截断值使全髋关节置换术后患者的患者报告结局无法获得有临床意义的改善。

Preoperative cut-off values for body mass index deny patients clinically significant improvements in patient-reported outcomes after total hip arthroplasty.

出版信息

Bone Joint J. 2020 Jun;102-B(6):683-692. doi: 10.1302/0301-620X.102B6.BJJ-2019-1644.R1.

Abstract

AIMS

Thresholds for operative eligibility based on body mass index (BMI) alone may restrict patient access to the benefits of arthroplasty. The purpose of this study was to evaluate the relationship between BMI and improvements in patient-reported outcome measures (PROMs), and to determine how many patients would have been denied improvements in PROMs if BMI cut-offs were to be implemented.

METHODS

A prospective cohort of 3,449 primary total hip arthroplasties (THAs) performed between 2015 and 2018 were analyzed. The following one-year PROMs were evaluated: hip injury and osteoarthritis outcome score (HOOS) pain, HOOS Physical Function Shortform (PS), University of California, Los Angeles (UCLA) activity, Veterans Rand-12 Physical Component Score (VR-12 PCS), and VR-12 Mental Component Score (VR-12 MCS). Positive predictive values for failure to improve and the number of patients denied surgery in order to avoid a failed improvement were calculated for each PROM at different BMI cut-offs.

RESULTS

There was a trend to improved outcomes in terms of pain and function improvements with higher BMI. Patients with BMI ≥ 40 kg/m had median (Q1, Q3) HOOS pain improvements of 58 points (interquartile range (IQR) 41 to 70) and those with BMI 35 to 40 kg/m had median improvements of 55 (IQR 40 to 68). With a BMI cut-off of 30 kg/m, 21 patients would have been denied a meaningful improvement in HOOS pain score in order to avoid one failed improvement. At a 35 kg/m cut-off, 18 patients would be denied improvement, at a 40 kg/m cut-off 21 patients would be denied improvement, and at a 45 kg/m cut-off 21 patients would be denied improvement. Similar findings were observed for HOOS-PS, UCLA, and VR-12 scores.

CONCLUSION

Patients with higher BMIs show greater improvements in PROMs. Using BMI alone to determine eligibility criteria did not improve the rate of clinically meaningful improvements. BMI thresholds prevent patients who may benefit the most from surgery from undergoing THA. Surgeons should consider PROMs improvements in determining eligibility for THA while balancing traditional metrics of preoperative risk stratification. Cite this article: 2020;102-B(6):683-692.

摘要

目的

仅基于体重指数(BMI)确定手术适应证的阈值可能会限制患者从关节置换中获益。本研究旨在评估 BMI 与患者报告的结果测量值(PROM)改善之间的关系,并确定如果实施 BMI 截止值,有多少患者会被拒绝改善 PROM。

方法

对 2015 年至 2018 年间进行的 3449 例初次全髋关节置换术(THA)的前瞻性队列进行了分析。评估了以下一年的 PROM:髋关节损伤和骨关节炎结果评分(HOOS)疼痛、HOOS 物理功能简明表(PS)、加利福尼亚大学洛杉矶分校(UCLA)活动量表、退伍军人 Rand-12 物理成分评分(VR-12 PCS)和 VR-12 心理成分评分(VR-12 MCS)。计算了每个 PROM 在不同 BMI 截止值下无法改善的阳性预测值和为避免改善失败而拒绝手术的患者数量。

结果

BMI 较高的患者疼痛和功能改善呈改善趋势。BMI≥40kg/m²的患者 HOOS 疼痛改善的中位数(Q1、Q3)为 58 分(四分位距(IQR)为 41 至 70),BMI 为 35 至 40kg/m²的患者的中位数改善为 55(IQR 为 40 至 68)。如果 BMI 截止值为 30kg/m²,为避免一次改善失败,将有 21 名患者被拒绝 HOOS 疼痛评分的有意义改善。如果 BMI 截止值为 35kg/m²,将有 18 名患者被拒绝改善,BMI 截止值为 40kg/m²,将有 21 名患者被拒绝改善,BMI 截止值为 45kg/m²,将有 21 名患者被拒绝改善。HOOS-PS、UCLA 和 VR-12 评分也有类似的发现。

结论

BMI 较高的患者在 PROM 方面有更大的改善。单独使用 BMI 来确定适应证标准并不能提高临床意义上的改善率。BMI 阈值会阻止那些最有可能从手术中受益的患者接受 THA。外科医生在确定 THA 的适应证时,应考虑 PROM 的改善,同时平衡术前风险分层的传统指标。

引用本文

2020;102-B(6):683-692。

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