Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, 128 Shenyang Road, Yangpu District, Shanghai, 200090, People's Republic of China.
J Ovarian Res. 2020 May 31;13(1):62. doi: 10.1186/s13048-020-00659-y.
Malignant transformation such as ovarian squamous cell carcinoma (SCC) in ovarian mature cystic teratoma (OMCT) is a rare tumor. The gene mutation of ovarian SCC remains unclear. We herein report a recurrent case of ovarian squamous cell carcinoma with MET gene copy number variation.
A 60-year-old woman presented with recurrence of ovarian SCC 8 months after primary surgery. Adhesiolysis, right abdominal wall mass excision, prosthetics, enterectomy, enterostomy and partial cystectomy were performed by laparoscope. Pathologic examination demonstrated metastatic squamous cell carcinoma in ileocecus, rectum and abdominal wall muscle. MET gene copy number was elevated with copy number of six in this case. Postoperatively, the patient was treated with four cycles of combination chemotherapy with docetaxel and carboplatin. The patient was free of disease at 20 months' follow-up.
Optimal cytoreductive surgery combined with platinum-based chemotherapy is recommended currently for not only primary tumor but also recurrence. For patients with malignant transformation in OMCT, prompt diagnosis and individualized treatment are crucial for better prognosis. Increased copy number of MET may be correlated with her poor PFS and can be a potential therapeutic target for this case.
卵巢成熟囊性畸胎瘤（OMCT）中发生恶性转化，如卵巢鳞状细胞癌（SCC），是一种罕见的肿瘤。卵巢 SCC 的基因突变尚不清楚。本文报告了一例伴有 MET 基因拷贝数变异的复发性卵巢鳞状细胞癌病例。
一名 60 岁女性，因原发性手术后 8 个月出现卵巢 SCC 复发而就诊。通过腹腔镜进行粘连松解、右腹壁肿块切除、假体植入、肠切除术、肠造口术和部分囊切除术。病理检查示回盲部、直肠和腹壁肌肉转移性鳞状细胞癌。本例 MET 基因拷贝数升高，拷贝数为六。术后，患者接受了四个周期的多西他赛和顺铂联合化疗。随访 20 个月无疾病进展。
目前推荐对原发性肿瘤和复发性肿瘤进行最佳的肿瘤细胞减灭术联合铂类为基础的化疗。对于 OMCT 中的恶性转化患者，及时诊断和个体化治疗对改善预后至关重要。MET 拷贝数增加可能与她的无进展生存期（PFS）较差相关，可能是该病例的潜在治疗靶点。
