Department of Gynecology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Department of Nuclear medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
J Ovarian Res. 2020 Nov 30;13(1):141. doi: 10.1186/s13048-020-00744-2.
Epithelial ovarian cancer (EOC) has the worst prognosis in all of gynecologic malignant tumors because of its high recurrence and eventually chemo-resistance. Early diagnosis of recurrence is crucial to avoid diffuse dissemination. Failure of traditional treatment in recurrent epithelial ovarian cancer remains a challenge for clinicians. On the other hand, I brachytherapy has been accepted as a useful and hopeful treatment for multiple advanced cancers in recent years. However, its success in advanced epithelial ovarian cancer is limited. Here we report a case of recurrent ovarian cancer who had been early diagnosis of isolated recurrence and successfully treated with I seeds implantation during suboptimal cytoreductive surgery.
A 59-year-old woman presented with recurrent epithelial ovarian cancer who have had a history of ovarian cancer stage IIIB and an R0 resection had been achieved nearly 2 years before presented in our hospital. She underwent suboptimal secondary cytoreductive surgery after four cycles of chemotherapy with little effectiveness and severe chemotherapy-related side effects. Approximately 70% of the cancer-bulk was resected during surgery. For residual lesion which fixed around the right ureter and right external iliac vessel, I seeds implantation was performed. Postoperatively, the patient was treated with two cycles of combination chemotherapy with paclitaxel and carboplatin. The patient was free of disease at 26 months' follow-up period.
In recurrent EOC patients with unresectable isolated lesion, salvage 125I seeds implantation are feasible and may contribute to survival.
上皮性卵巢癌（EOC）因其高复发率和最终的化疗耐药性，在所有妇科恶性肿瘤中预后最差。早期诊断复发对于避免广泛扩散至关重要。复发性上皮性卵巢癌的传统治疗失败仍然是临床医生面临的挑战。另一方面，近年来近距离放射治疗已被接受为多种晚期癌症的有用且有希望的治疗方法。然而，其在晚期上皮性卵巢癌中的成功有限。本文报告了一例复发性卵巢癌患者，该患者在不理想的细胞减灭术后成功接受了 I 种子植入治疗，从而早期诊断为孤立性复发。
一名 59 岁女性因复发性上皮性卵巢癌就诊，该患者曾患有 IIIB 期卵巢癌，在近 2 年前于我院行卵巢癌 R0 切除术。在接受了四个周期的化疗（效果不佳且伴有严重的化疗相关副作用）后，她接受了次优的二次细胞减灭术。手术切除了约 70%的肿瘤肿块。对于固定在右侧输尿管和右侧髂外血管周围的残留病变，进行了 I 种子植入术。术后，患者接受了两个周期的紫杉醇联合卡铂联合化疗。在 26 个月的随访期间，患者无疾病。
对于无法切除的孤立性复发性上皮性卵巢癌患者，挽救性 125I 种子植入是可行的，并且可能有助于生存。
