Postgraduate Program in Pharmaceutical Sciences, Laboratory of Research and Development of Drug Delivery Systems, Department of Pharmacy, State University of Maringa, 87020-900, Maringa, PR, Brazil.
Research Centre in Topical Drug Delivery and Toxicology, Department of Clinical and Pharmaceutical Science, University of Hertfordshire, Hatfield, AL10 9AB, United Kingdom.
Carbohydr Polym. 2020 Jul 15;240:116268. doi: 10.1016/j.carbpol.2020.116268. Epub 2020 Apr 15.
Poloxamer 407 (polox407) is widely studied as thermogelling polymer, transitioning to a gel state when warmed Polox407 forms weak hydrogels with rapid dissolution in excess solvent. This study reports the development of binary systems composed of polox407 and hydroxypropyl methylcellulose (HPMC) or sodium carboxymethylcellulose (NaCMC) aiming to improve the rheological and mechanical properties of the hydrogel. The interaction between polox407 and cellulose derivatives was studied, and their interaction with biological surfaces predicted. The carbohydrates affected the mechanical and rheological behavior of polox407 in different ways, dependent on polymer type, concentration, and temperature. T and rheological interaction parameters were useful to select the most suitable formulations for topical or local application. Most of the binary systems exhibited plastic behavior, thixotropy and viscoelastic properties. Appropriate formulations were identified for local application, such as 17.5/3; 17.5/4; 20/3 and 20/4 (%, w/w) for polox407/HPMC; and 17.5/1; 17.5/1.5; 20/1 and 20/1.5 (%, w/w) for polox407/NaCMC.
泊洛沙姆 407（polox407）作为一种温敏聚合物被广泛研究，当加热时会转变为凝胶状态。泊洛沙姆 407 与过量溶剂快速溶解形成弱水凝胶。本研究报告了由泊洛沙姆 407 和羟丙基甲基纤维素（HPMC）或羧甲基纤维素钠（NaCMC）组成的二元系统的开发，旨在改善水凝胶的流变和机械性能。研究了泊洛沙姆 407 与纤维素衍生物之间的相互作用，并预测了它们与生物表面的相互作用。碳水化合物以不同的方式影响泊洛沙姆 407 的机械和流变行为，这取决于聚合物类型、浓度和温度。T 和流变相互作用参数可用于选择最适合局部或局部应用的配方。大多数二元系统表现出塑性行为、触变性和粘弹性。确定了适合局部应用的适当配方，例如泊洛沙姆 407/HPMC 的 17.5/3；17.5/4；20/3 和 20/4（%，w/w）；以及泊洛沙姆 407/NaCMC 的 17.5/1；17.5/1.5；20/1 和 20/1.5（%，w/w）。
