Department of Otolaryngology, Faculty of Medicine, Bozok University, Atatürk Yolu 7. Km, 66100, Yozgat, Turkey.
Department of General Surgery, Faculty of Medicine, Bozok University, Yozgat, Turkey.
Eur Arch Otorhinolaryngol. 2020 Oct;277(10):2761-2765. doi: 10.1007/s00405-020-06089-2. Epub 2020 May 31.
This study aimed to investigate the relationship between the presence of gastric Helicobacter pylori (HP) infection and nasal mucociliary clearance (NMC) time and to analyze the effect of HP eradication on NMC time.
Patients who underwent gastric biopsy and had a positive result for HP constituted the study group, while the control group consisted of the patients who had a negative biopsy result. Two groups were compared in terms of NMC times. Quadruple medication therapy was given to HP-positive patients for 14 days for eradication and NMC time was measured again in these patients 8 weeks after eradication. Statistical analyses were performed with SPSS software (version 22.0; SPSS, Chicago, Illinois, USA).
There were 60 patients in the study group (HP +), while the control group (HP -) included 50 patients. Mean NMC times were 12.86 ± 2.62 and 8.32 ± 2.24 for the study and control groups, respectively (p < 0.001). Pre- and post-eradication mean NMC times of the HP + patients were 12.71 ± 2.58 and 8.62 ± 1.39, respectively (p < 0.001).
We determined that NMC time was significantly higher in HP-positive patients when compared with HP-negative patients, and the NMC times went back to normal after eradicating the HP infection. Because NMC dysfunction plays an essential role in the pathogenesis of chronic rhinosinusitis (CRS), we propose that eradication of HP can have positive effects on the prognosis of CRS. Further studies are needed to establish this relationship.
本研究旨在探讨胃幽门螺杆菌（HP）感染与鼻黏膜纤毛清除（NMC）时间的关系，并分析 HP 根除对 NMC 时间的影响。
接受胃活检且 HP 检测结果阳性的患者为研究组，活检结果阴性的患者为对照组。比较两组的 NMC 时间。对 HP 阳性患者给予四联药物治疗 14 天进行根除，根除后 8 周再次测量 NMC 时间。采用 SPSS 软件（版本 22.0；SPSS，美国伊利诺伊州芝加哥）进行统计学分析。
研究组（HP+）有 60 例患者，对照组（HP-）有 50 例患者。研究组和对照组的平均 NMC 时间分别为 12.86±2.62 和 8.32±2.24（p<0.001）。HP+患者根除前后的平均 NMC 时间分别为 12.71±2.58 和 8.62±1.39（p<0.001）。
我们发现 HP 阳性患者的 NMC 时间明显高于 HP 阴性患者，根除 HP 感染后 NMC 时间恢复正常。由于 NMC 功能障碍在慢性鼻-鼻窦炎（CRS）的发病机制中起重要作用，我们提出根除 HP 可能对 CRS 的预后产生积极影响。需要进一步的研究来建立这种关系。
