幽门螺杆菌感染患者鼻黏膜纤毛清除功能的评估。
The evaluation of nasal mucociliary clearance in patients with Helicobacter pylori infection.
作者信息
Üstün Bezgin S, Çakabay T, Irak K, Koçyiğit M, Serin Keskineğe B, Giran Örtekin S
机构信息
Department of Otorhinolaryngology,Kanuni Sultan Süleyman Training and Research Hospital,Istanbul,Turkey.
Department of Gastroenterology,Kanuni Sultan Süleyman Training and Research Hospital,Istanbul,Turkey.
出版信息
J Laryngol Otol. 2019 Mar;133(3):220-223. doi: 10.1017/S0022215119000136. Epub 2019 Feb 6.
OBJECTIVE
This study aimed to examine nasal mucociliary clearance time in patients with Helicobacter pylori infection.
METHODS
Fifty patients who were newly diagnosed with H pylori infection using gastric biopsy in the gastroenterology out-patient clinic, and 50 age- and gender-matched healthy adults who were admitted to the otorhinolaryngology out-patient clinic, were included in this study. After an otorhinolaryngological examination (anterior rhinoscopy and nasal endoscopic examination), the nasal mucociliary clearance time of each subject was calculated using the saccharine test.
RESULTS
The mean mucociliary clearance time was 06:29 ± 3:31 minutes (range, 00:55-15:19 minutes) in the control group and 10:12 ± 06:09 minutes (range, 01:28-32:00 minutes) in the study group. Comparisons of the two groups revealed a statistically significant difference (p = 0.002).
CONCLUSION
Nasal mucociliary clearance time was significantly increased in patients with H pylori infection. The results suggest that H pylori infection may have an unfavourable effect on nasal mucociliary clearance.
目的
本研究旨在检测幽门螺杆菌感染患者的鼻黏液纤毛清除时间。
方法
本研究纳入了50例在胃肠病门诊通过胃活检新诊断为幽门螺杆菌感染的患者，以及50例在耳鼻喉门诊就诊的年龄和性别匹配的健康成年人。在进行耳鼻喉科检查（前鼻镜检查和鼻内镜检查）后，使用糖精试验计算每个受试者的鼻黏液纤毛清除时间。
结果
对照组的平均黏液纤毛清除时间为06:29 ± 3:31分钟（范围为00:55 - 15:19分钟），研究组为10:12 ± 06:09分钟（范围为01:28 - 32:00分钟）。两组比较显示差异有统计学意义（p = 0.002）。
结论
幽门螺杆菌感染患者的鼻黏液纤毛清除时间显著延长。结果表明，幽门螺杆菌感染可能对鼻黏液纤毛清除产生不利影响。
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