Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, China.
Department of Orthopaedics, Zhongshan Hospital, Fudan University , Shanghai, China.
Expert Rev Clin Immunol. 2020 Jun;16(6):631-640. doi: 10.1080/1744666X.2020.1777098. Epub 2020 Jun 30.
Currently published papers regarding the relationship between integrin alpha V (ITGAV) gene polymorphisms and rheumatoid arthritis (RA) are contradictory. The aim of this meta-analysis was to evaluate the associations between the ITGAV gene polymorphisms and RA risk.
Comprehensive literature search based on four electronic databases was applied to retrieve all related data. Two independent reviewers screened each article for eligibility according to the predetermined inclusion criteria. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to assess associations between ITGAV gene polymorphisms and RA.
Six articles involving 5794 RA patients and 5297 healthy controls were included in this meta-analysis. The combined data indicated that rs3911238, rs3738919, rs3768777, and rs10174098 in ITGAV gene were not associated with RA risk in the overall population. However, stratification analysis by ethnicity suggested that rs3768777 was related with risk of RA among Caucasian population (OR 3.51, 95%CI 2.06, 5.97; P < 0.0001), but not among Asian population (OR 1.06, 95%CI 0.67, 1.69; P = 0.81).
Our meta-analysis confirmed that the ITGAV gene rs3768777 polymorphisms might be a risk factor among Caucasians. However, larger-scale studies in Caucasian population are still warranted to confirm the findings of our study.
目前发表的关于整合素 αV（ITGAV）基因多态性与类风湿关节炎（RA）之间关系的论文存在矛盾。本荟萃分析的目的是评估 ITGAV 基因多态性与 RA 风险之间的关系。
根据四个电子数据库进行全面文献检索，以检索所有相关数据。两名独立评审员根据预定的纳入标准筛选每篇文章的资格。使用合并优势比（OR）和 95%置信区间（95%CI）来评估 ITGAV 基因多态性与 RA 之间的关联。
本荟萃分析纳入了 6 篇文章，涉及 5794 例 RA 患者和 5297 例健康对照者。合并数据表明，ITGAV 基因中的 rs3911238、rs3738919、rs3768777 和 rs10174098 与总体人群的 RA 风险无关。然而，按种族进行分层分析表明，rs3768777 与高加索人群的 RA 风险相关（OR 3.51，95%CI 2.06，5.97；P < 0.0001），但与亚洲人群无关（OR 1.06，95%CI 0.67，1.69；P = 0.81）。
本荟萃分析证实，ITGAV 基因 rs3768777 多态性可能是高加索人群的一个危险因素。然而，仍需要在高加索人群中进行更大规模的研究来证实本研究的结果。
