Wujcicka Wioletta Izabela, Kacerovsky Marian, Krekora Michał, Kaczmarek Piotr, Leśniczak Beata, Grzesiak Mariusz
Scientific Laboratory of the Center of Medical Laboratory Diagnostics and Screening, Polish Mother's Memorial Hospital-Research Institute, 93-338 Lodz, Poland.
Department of Obstetrics and Gynecology, University Hospital Hradec Kralove, Charles University, 500 03 Hradec Kralove, Czech Republic.
Biology (Basel). 2022 Mar 16;11(3):447. doi: 10.3390/biology11030447.
Fetal growth restriction (FGR) is a condition that characterizes fetuses as too small for their gestational age, with an estimated fetal weight (EFW) below the 10th percentile and abnormal Doppler parameters and/or with EFW below the 3rd percentile. We designed our study to demonstrate the contribution of single nucleotide polymorphisms (SNPs) from DLX3 (rs11656951, rs2278163, and rs10459948), HLX (rs2184658, and 868058), ANGPT2 (−35 G > C), and ITGAV (rs3911238, and rs3768777) genes in maternal blood in FGR. A cohort of 380 women with singleton pregnancies consisted of 190 pregnancies with FGR and 190 healthy full-term controls. A comparison of the pregnancies with an early-onset FGR and healthy subjects showed that the AT heterozygotes in HLX rs868058 were significantly associated with an approximately two-fold increase in disease risk (p ≤ 0.050). The AT heterozygotes in rs868058 were significantly more frequent in the cases with early-onset FGR than in late-onset FGR in the overdominant model (OR 2.08 95% CI 1.11−3.89, p = 0.022), and after being adjusted by anemia, in the codominant model (OR 2.45 95% CI 1.23−4.90, p = 0.034). In conclusion, the heterozygous AT genotype in HLX rs868058 can be considered a significant risk factor for the development of early-onset FGR, regardless of adverse pregnancy outcomes in women.
胎儿生长受限（FGR）是一种胎儿因孕周而相对过小的情况，估计胎儿体重（EFW）低于第10百分位数且多普勒参数异常，和/或EFW低于第3百分位数。我们设计本研究以证明DLX3（rs11656951、rs2278163和rs10459948）、HLX（rs2184658和868058）、ANGPT2（-35 G>C）和ITGAV（rs3911238和rs3768777）基因的单核苷酸多态性（SNP）在FGR孕妇血液中的作用。一项对380名单胎妊娠女性的队列研究包括190例FGR妊娠和190例健康足月对照。早发型FGR妊娠与健康受试者的比较表明，HLX rs868058的AT杂合子与疾病风险增加约两倍显著相关（p≤0.050）。在超显性模型中，rs868058的AT杂合子在早发型FGR病例中比晚发型FGR更常见（OR 2.08，95%CI 1.11-3.89，p=0.022），在经贫血校正后，在共显性模型中（OR 2.45，95%CI 1.23-4.90，p=0.034）。总之，无论女性的不良妊娠结局如何，HLX rs868058的杂合子AT基因型可被视为早发型FGR发生的显著危险因素。
