School of Medicine, Institute of Medical Research A Lanari, University of Buenos Aires, Buenos Aires, Argentina.
Department of Molecular Genetics and Biology of Complex Diseases, National Scientific and Technical Research Council (Conicet)-university of Buenos Aires. Institute of Medical Research (IDIM).
Expert Rev Gastroenterol Hepatol. 2022 Jun;16(6):521-536. doi: 10.1080/17474124.2020.1765772. Epub 2020 Jun 1.
: Fatty liver disease, defined by the presence of liver fat infiltration, is part of a cluster of disorders that occur in the context of metabolic syndrome. Epigenetic factors - defined as stable and heritable changes in gene expression without changes in the DNA sequence - may not only play an important role in the disease development in adulthood, but they may start exerting their influence in the prenatal stage.: By using systems biology approaches, we review the main epigenetic modifications and highlight their likely roles in the pathogenesis of nonalcoholic fatty liver disease.: Knowledge of the mechanisms by which epigenetic modifications participate in complex disorders would not only help scientists find novel therapeutic strategies but could also aid in implementing preventive care measures at gestation.
: 脂肪性肝病是指肝脏脂肪浸润的存在，它是代谢综合征背景下发生的一系列疾病的一部分。表观遗传因素（定义为基因表达的稳定且可遗传的变化，而 DNA 序列不变）不仅可能在成年期疾病发展中发挥重要作用，而且可能在产前阶段就开始发挥作用。: 通过使用系统生物学方法，我们回顾了主要的表观遗传修饰，并强调了它们在非酒精性脂肪性肝病发病机制中的可能作用。: 了解表观遗传修饰参与复杂疾病的机制不仅有助于科学家寻找新的治疗策略，还可以帮助在妊娠期间实施预防保健措施。
