胆甾烷醇假定前体的色谱分离。
Chromatographic separation of putative precursors of cholestanol.
作者信息
Batta A K, Salen G, Shefer S
机构信息
Department of Medicine, UMDNJ-New Jersey Medical School, Newark 07103.
出版信息
Steroids. 1988 Jul-Aug;52(1-2):109-22. doi: 10.1016/0039-128x(88)90220-6.
This paper describes convenient syntheses for labeled and unlabeled cholest-5-en-3-one, cholest-4-en-3-one, epicholesterol, cholest-4-en-3 beta-ol, and cholest-4-en-3 alpha-ol. The thin-layer chromatography, high-performance liquid chromatography, and gas-liquid chromatography of these compounds and of cholestanol and epicholestanol are also described. The synthesized compounds are potential precursors in the biosynthesis of cholestanol in mammals.
本文描述了标记和未标记的胆甾-5-烯-3-酮、胆甾-4-烯-3-酮、表胆固醇、胆甾-4-烯-3β-醇和胆甾-4-烯-3α-醇的简便合成方法。还描述了这些化合物以及胆甾烷醇和表胆甾烷醇的薄层色谱、高效液相色谱和气液色谱。合成的化合物是哺乳动物中胆甾烷醇生物合成的潜在前体。
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