突尼斯白塞病临床表现的变化模式：两个十年的比较。
Changing pattern of clinical manifestations of Behçet's disease in Tunisia: comparison between two decades.
作者信息
Ksiaa Imen, Kechida Melek, Abroug Nesrine, Bchir Sabri, Attia Sonia, Khochtali Sana, Khairallah Moncef
机构信息
Department of Ophthalmology, Fattouma Bourguiba University Hospital, Faculty of Medicine, University of Monastir, Tunisia.
Department of Internal Medicine and Endocrinology, Fattouma Bourguiba University Hospital, Faculty of Medicine, University of Monastir, Tunisia.
出版信息
Reumatologia. 2020;58(2):87-92. doi: 10.5114/reum.2020.95362. Epub 2020 Apr 30.
OBJECTIVES
To investigate the changes over time in extraocular and ocular manifestations of Behçet's disease (BD) in Tunisian patients.
MATERIAL AND METHODS
Retrospective study of 246 patients divided into two groups: group 1 (147 patients examined from 1995 to 2005) and group 2 (99 patients examined from 2006 to 2017).
RESULTS
Active or scarred genital ulcers observed by physician at presentation were significantly less frequent in group 2 (47.2% vs. 29.6%; = 0.007), as were articular involvement (50.3% vs. 34.7%; = 0.016) and erythema nodosum (18.4% vs. 8.1%; = 0.024). One hundred-seven patients (43.5%) developed ocular manifestations during the 23-year study period. Intermediate uveitis was significantly more frequent in group 2 than in group 1 (11.7% vs. 28.4%; = 0.003), and posterior uveitis less frequent in group 2 than in group 1 (34.2% vs. 19.7%; = 0.016). Patients from group 2 were more likely to have macular edema (19.8% vs. 45.6%; = 0.001). However, better visual prognosis, with a lower rate of legal blindness, was noted in group 2.
CONCLUSIONS
Changes over time included a decrease in the rate of articular involvement and cutaneous involvement. There was an increase in the rate of intermediate uveitis and a decrease in the rate of posterior uveitis over time. Despite an increase in the rate of macular edema, there was an improvement in visual prognosis, with less legal blindness over time.
目的
研究突尼斯贝赫切特病（BD）患者眼外和眼部表现随时间的变化。
材料与方法
对246例患者进行回顾性研究，分为两组：第1组（1995年至2005年检查的147例患者）和第2组（2006年至2017年检查的99例患者）。
结果
第2组患者就诊时医生观察到的活动性或瘢痕性生殖器溃疡明显较少（47.2%对29.6%；P = 0.007），关节受累情况（50.3%对34.7%；P = 0.016）和结节性红斑（18.4%对8.1%；P = 0.024）也是如此。在23年的研究期间，107例患者（43.5%）出现眼部表现。第2组中间葡萄膜炎的发生率明显高于第1组（11.7%对28.4%；P = 0.003），第2组后葡萄膜炎的发生率低于第1组（34.2%对19.7%；P = 0.016）。第2组患者更易出现黄斑水肿（19.8%对45.6%；P = 0.001）。然而，第2组的视力预后较好，法定失明率较低。
结论
随时间变化包括关节受累和皮肤受累发生率降低。随着时间推移，中间葡萄膜炎发生率增加，后葡萄膜炎发生率降低。尽管黄斑水肿发生率增加，但视力预后有所改善，法定失明情况减少。
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