Saadouli Dorsaf, Mansour Khaoula Ben, Yahyaoui Salem, Afrit Naouel El, Lahmar Amel, Afrit Ali El
Department of Ophthalmology, Faculty of Medicine of Tunis, La Rabta Hospital, University of Tunis, El Manar, Tunisia.
Curr Aging Sci. 2021;14(1):56-61. doi: 10.2174/1874609813666200128110820.
Behçet's disease is frequent in Tunisia and potentially serious, which can endanger both the vital and visual prognosis. Late occurrence of the disease is uncommon and less frequently investigated. ; Aims: The aim of this study was to analyse the demographic characteristics and ocular manifestations of patients with late-onset Behçet disease in Tunisia, North Africa. ; Methods: A retrospective study was performed on 38 eyes of 21 oculo-Behçet patients over a seven- year period. ; Results: The mean age of our patients was 54.81 years. The sex ratio M/F was 2.5. The period between the onset of the first symptom and diagnosis of Behçet's disease varied from 3 days to 2 years. The primary complaint was a decrease in visual acuity, reported in 8 patients. Ocular involvement revealed Behçet's disease in 2 patients, bilateral in 17 patients, and active in 31 eyes. The ocular manifestations in late-onset Behçet's disease were dominated by uveal involvement (30 eyes). The most frequent form of uveitis was panuveitis noted in 13 eyes. Ocular complications were dominated by macular involvement in 8 patients (14 eyes). Blindness was noted in 4 eyes of 4 patients (10.5%). Topical corticosteroids were used in 30 eyes. Three patients were treated only with oral corticosteroid and 9 patients with a combination of oral corticosteroid and immunosuppressive agents. ; Conclusion: Since the course of the ocular involvement in late-onset Behçet's disease is regarded to be relatively mild, it is noteworthy that our study revealed that blindness was noted in 10,5% and posterior uveitis and panuveitis were the most common uveal lesion.
白塞病在突尼斯很常见且可能较为严重，会危及生命和视力预后。该病晚期发病并不常见，且较少受到研究。目的：本研究旨在分析北非突尼斯迟发性白塞病患者的人口统计学特征和眼部表现。方法：对21例眼白塞病患者的38只眼睛进行了为期7年的回顾性研究。结果：我们患者的平均年龄为54.81岁。男女比例为2.5。从首次出现症状到白塞病诊断的时间间隔为3天至2年。主要症状为视力下降，8例患者有此报告。眼部受累情况显示，2例患者确诊为白塞病，17例为双侧受累，31只眼睛处于活动期。迟发性白塞病的眼部表现以葡萄膜受累为主（30只眼）。最常见的葡萄膜炎类型是全葡萄膜炎，有13只眼。眼部并发症以黄斑受累为主，8例患者（14只眼）出现这种情况。4例患者的4只眼睛失明（10.5%）。30只眼睛使用了局部皮质类固醇。3例患者仅接受口服皮质类固醇治疗，9例患者接受口服皮质类固醇和免疫抑制剂联合治疗。结论：鉴于迟发性白塞病的眼部受累病程被认为相对较轻，值得注意的是，我们的研究显示失明率为10.5%，后葡萄膜炎和全葡萄膜炎是最常见的葡萄膜病变。
