Caruana Louis B, Redwine Gerald D, Rohde Rodney E, Russian Chris J
Texas State University Clinical Laboratory Science Program.
Texas State University Department of Respiratory Care.
Sarcoidosis Vasc Diffuse Lung Dis. 2019;36(3):228-242. doi: 10.36141/svdld.v36i3.7112. Epub 2019 May 1.
This original research is a directional study that determined the habits of individuals using four analyses to find statistical significance in the data collected from the surveys of 801 qualified of 1,340 individuals who agreed to participate. Results from the self-reported diagnosis of individuals affected by sarcoidosis produced seven statistically significant indicators of future research needed. The demographics revealed a significantly greater number of women and African-Americans participants than other minorities in the United States and suggested a sense of urgency to find a cure. Most important are the seven statistically significant findings that also gave credence to the researchers' four subdiagnostic classifications. They are acute sarcoidosis (AS) and chronic sarcoidosis with limited dissemination (CSLD), while more severe cases include those with chronic sarcoidosis with full dissemination including cutaneous involvement (CSFDIC) and chronic sarcoidosis with neurosarcoidosis (CSN). The most severe sarcoidosis cases (CSN) were on the "most likely" side of every statistically significant category except drinking alcohol, and the "least likely" to participate in physical activities. Conversely, the least severe case of sarcoidosis (AS) was the opposite. The complete list of statistically significant areas was related to alcohol use, tobacco use, ciprofloxacin use, environmental exposure to metals (copper, iron), infectious diseases (candidiasis), genetics, and physical exercise. Statistically, the most crucial study needed; emerged from the Rh blood grouping of the participants.
这项原创研究是一项定向研究，通过四种分析方法确定了个体的习惯，以在从1340名同意参与调查的个体中筛选出的801名合格个体所收集的数据中找到统计学意义。结节病患者自我报告诊断的结果产生了七个具有统计学意义的未来研究所需指标。人口统计学显示，与美国其他少数族裔相比，女性和非裔美国参与者的数量明显更多，这表明找到治愈方法的紧迫性。最重要的是七个具有统计学意义的发现，这些发现也证实了研究人员的四个亚诊断分类。它们是急性结节病（AS）和播散受限的慢性结节病（CSLD），而更严重的病例包括伴有全身播散包括皮肤受累的慢性结节病（CSFDIC）和伴有神经结节病的慢性结节病（CSN）。除饮酒外，最严重的结节病病例（CSN）在每个具有统计学意义的类别中都处于“最有可能”的一方，并且最“不可能”参与体育活动。相反，最不严重的结节病病例（AS）则相反。具有统计学意义的领域的完整列表与饮酒、吸烟、使用环丙沙星、环境接触金属（铜、铁）、传染病（念珠菌病）、遗传学和体育锻炼有关。从统计学角度来看，最关键的研究需求来自参与者的Rh血型分组。
