Ungprasert Patompong, Carmona Eva M, Utz James P, Ryu Jay H, Crowson Cynthia S, Matteson Eric L
Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN.
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN.
Mayo Clin Proc. 2016 Feb;91(2):183-8. doi: 10.1016/j.mayocp.2015.10.024. Epub 2015 Dec 22.
To characterize the epidemiology of sarcoidosis from 1946 through 2013.
An inception cohort of patients with incident sarcoidosis from January 1, 1976, through December 31, 2013, in Olmsted County, Minnesota, was identified based on comprehensive individual medical record review. Inclusion required physician diagnosis supported by histopathologic confirmation, radiologic features of intrathoracic sarcoidosis, and a compatible clinical presentation. Data were collected on demographic characteristics, clinical presentation, laboratory investigations, and mortality. The data were augmented with a previously identified cohort of Olmsted County residents diagnosed as having sarcoidosis in 1946-1975. Incidence rates were age and sex adjusted to the 2010 US white population.
A total of 448 incident cases of sarcoidosis were identified (mean age, 44.2 years; 52% women). The annual incidence of sarcoidosis was 10.0 per 100,000 population. The incidence of sarcoidosis increased in women from 1950 to 1960, but otherwise there were no significant calendar year trends. However, the peak age at incidence for women shifted from 40 to 59 years in 1950 to 50 to 69 years in 2010. Similarly, the peak age at incidence for men shifted from 30 to 49 years in 1950 to 40 to 59 years in 2010. Ninety-seven percent of patients had intrathoracic involvement, but only 43% had respiratory symptoms. The overall mortality of patients with sarcoidosis was not different from that of the general population (standardized mortality ratio=0.90; 95% CI, 0.74-1.08).
Sarcoidosis occurred in approximately 10 persons per 100,000 per year. Most of the patients had intrathoracic involvement, although less than half had respiratory symptoms. Overall mortality was not different from that of the general population.
描述1946年至2013年结节病的流行病学特征。
通过全面查阅个人病历，确定了1976年1月1日至2013年12月31日在明尼苏达州奥尔姆斯特德县新确诊结节病的患者队列。纳入标准要求有医师诊断，并得到组织病理学证实、胸内结节病的放射学特征及相符的临床表现支持。收集了人口统计学特征、临床表现、实验室检查及死亡率等数据。这些数据与之前确定的1946 - 1975年被诊断为结节病的奥尔姆斯特德县居民队列数据相结合。发病率按年龄和性别调整至2010年美国白人人口水平。
共确定448例新确诊的结节病病例（平均年龄44.2岁；52%为女性）。结节病的年发病率为每10万人10.0例。1950年至1960年女性结节病发病率上升，但除此之外，发病年份无明显趋势。然而，女性发病高峰年龄从1950年的40至59岁变为2010年的50至69岁。同样，男性发病高峰年龄从1950年的30至49岁变为2010年的40至59岁。97%的患者有胸内受累，但只有43%有呼吸道症状。结节病患者的总体死亡率与普通人群无异（标准化死亡率=0.90；95%可信区间，0.74 - 1.08）。
结节病的年发病率约为每10万人10例。大多数患者有胸内受累，尽管不到一半有呼吸道症状。总体死亡率与普通人群无异。
