Yalnız Enver, Polat Gulru, Demirci Fatma, Deniz Sami, Karadeniz Gulistan, Aydınlı Esra, Vayisoglu Gorkem, Ayrancı Aysu
Health Science University Dr.Suat Seren Chest Diseases and Surgery Research and Training Hospital.
Sarcoidosis Vasc Diffuse Lung Dis. 2019;36(4):294-301. doi: 10.36141/svdld.v36i4.8418. Epub 2019 May 1.
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease (ILD) with unknown etiology that occurs primarily in older adults with a median survival time of 2.5±3.5 years. Since there is no curative treatment for IPF, patients with IPF may have symptoms of depression and anxiety more than those of other interstitial lung diseases. There is a few studies about comparison of anxiety depression with other interstitial lung disease and IPF. In this study, we investigated whether anxiety depression in IPF was more frequent than other ILDs and its effect on quality of life.
The study was designed as a prospective study. Age, sex, smoking status, respiratory symptoms, comorbidities, pulmonary function tests, diffusion capacity of the lungs for carbon monoxide (TLCO), SF-36, and depression/anxiety levels, radiological findings, erythrocyte sedimentation rate (ESR), CRP level, blood gas analysis, complete blood count parameters were recorded.
The mean age of 50 IPF and 42 non-IPF interstitial lung disease patients were 67.4±7.1 and 64.9±7.2, respectively. Compared with the non-IPF group, SF-36 total, SF-36 physical function and SF-36 physical role severity were significantly lower in the IPF group, while the GAP score was significantly higher. There was no significant difference between the two groups in HAM-Anxiety and HAM-depression for total scores. But mild anxiety was present in most of non-IPF group. No severe anxiety was observed in this group. Forty-nine of 50 patients with IPF patients had moderate-severe anxiety and the difference was statistically significant compared to non-IPF patients.
This is one of the first studies of anxiety and depression symptoms are also important in non IPF ILD like IPF. Patients with non-IPF ILD have similar anxiety depression with IPF patients in this study. This study led to the conclusion that anxiety depression should also be evaluated in non-IPF ILD patients.
特发性肺纤维化（IPF）是一种病因不明的慢性进行性间质性肺疾病（ILD），主要发生于老年人，中位生存时间为2.5±3.5年。由于IPF尚无治愈性治疗方法，与其他间质性肺疾病患者相比，IPF患者可能更易出现抑郁和焦虑症状。关于IPF与其他间质性肺疾病焦虑抑郁情况比较的研究较少。在本研究中，我们调查了IPF患者的焦虑抑郁是否比其他ILD更常见及其对生活质量的影响。
本研究设计为前瞻性研究。记录年龄、性别、吸烟状况、呼吸道症状、合并症、肺功能测试、肺一氧化碳弥散量（TLCO）、SF-36、抑郁/焦虑水平、影像学检查结果、红细胞沉降率（ESR）、CRP水平、血气分析、全血细胞计数参数。
50例IPF患者和42例非IPF间质性肺疾病患者的平均年龄分别为67.4±7.1岁和64.9±7.2岁。与非IPF组相比，IPF组的SF-36总分、SF-36身体功能和SF-36身体角色严重程度显著降低，而GAP评分显著升高。两组在HAM-焦虑和HAM-抑郁总分方面无显著差异。但大多数非IPF组存在轻度焦虑。该组未观察到严重焦虑。50例IPF患者中有49例存在中度至重度焦虑，与非IPF患者相比差异有统计学意义。
这是首批研究之一，表明焦虑和抑郁症状在非IPF的ILD中也很重要，如同在IPF中一样。在本研究中，非IPF的ILD患者与IPF患者有相似的焦虑抑郁情况。本研究得出结论，非IPF的ILD患者也应评估焦虑抑郁情况。
