Pack Gary D, Craven Mark, Acharya Amit
University of Wisconsin-Madison, Madison, WI.
Center for Oral and Systemic Health, Marshfield Clinic, Marshfield, WI.
AMIA Jt Summits Transl Sci Proc. 2020 May 30;2020:477-486. eCollection 2020.
Diabetes mellitus is the putative cause of a number of pathologies occurring in the bony and soft tissues of the maxillo-facial region and is known to exacerbate other oral diseases such as periodontitis.We present the first use of clinical panoramic radiographs for a secondary analysis of disease, with a focus on identifying hotspots in the maxillofacial region that are associated with diabetes. We developed a curated data set using Consensus Landmark Points (CLPs) and used that data to develop an analysis pipeline. This pipeline entailed automatic data cleansing, registration, and intensity normalization. The pipeline was used to process 7280 uncurated images that were subsequently analyzed using pixel-wise methods for a case/control study of patients with a history of diabetes. We detected statistically significant clusters of pixels that demarcated anatomical hotspots specific to the diabetic patients.
糖尿病被认为是上颌面部区域骨骼和软组织中多种病变的病因，并且已知会加剧其他口腔疾病，如牙周炎。我们首次使用临床全景X光片对疾病进行二次分析，重点是识别上颌面部区域与糖尿病相关的热点。我们使用共识地标点（CLP）开发了一个经过整理的数据集，并使用该数据开发了一个分析流程。这个流程包括自动数据清理、配准和强度归一化。该流程用于处理7280张未经整理的图像，随后使用逐像素方法对有糖尿病病史的患者进行病例/对照研究分析。我们检测到具有统计学意义的像素簇，这些像素簇划定了糖尿病患者特有的解剖热点。
