ETS1 Suppresses Tumorigenesis of Human Breast Cancer via Trans-Activation of Canonical Tumor Suppressor Genes.

has shown dichotomous roles as an oncogene and a tumor suppressor gene in diverse cancers, but its functionality in breast cancer tumorigenesis still remains unclear. We utilized the Cancer Genome Atlas (TCGA) database to analyze comprehensive functions of in human breast cancer (BRCA) patients by investigating its expression patterns and methylation status in relation to clinical prognosis. expression was significantly diminished by hyper-methylation of the promoter region in specimens from BRCA patients compared to a healthy control group. Moreover, BRCA patients showed better prognosis and longer survival compared to BRCA patients. Consistent with clinical evidence, comparative transcriptome analysis combined with CRISPR/Cas9 or shRNA based perturbation of expression revealed direct as well as indirect mechanisms of that hinder tumorigenesis of BRCA cells. Taken together, our study enlightens a novel function of as a tumor suppressor in breast cancer cells.