角鲨酰胺A及其类似物的全合成与生物学评价
Total Synthesis and Biological Evaluation of Kakeromamide A and Its Analogues.
作者信息
Zhao Meng, Xiao Yi, Otsuka Satoshi, Nakao Yoichi, Guo Yian, Ye Tao
机构信息
State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Shenzhen, China.
Research Institute for Science and Engineering, Waseda University, Tokyo, Japan.
出版信息
Front Chem. 2020 May 13;8:410. doi: 10.3389/fchem.2020.00410. eCollection 2020.
Abstract
Kakeromamide A (), the first marine cyclopeptide inducing neural stem cells differentiation into astrocytes, was synthesized in 12 longest linear steps and 14% overall yield. Using this synthetic approach, four analogs of kakeromamide A were prepared and evaluated for neural differentiation- modulating activity.
摘要
卡克罗马酰胺A（）是首个诱导神经干细胞分化为星形胶质细胞的海洋环肽，通过12步最长线性步骤合成，总产率为14%。采用这种合成方法，制备了卡克罗马酰胺A的四种类似物，并对其神经分化调节活性进行了评估。
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