Fedele L, Marchini M, Baglioni A, Dorta M, Candiani G B
1 Clinica Ostetrica e Ginecologica L. Mangiagalli, Universitá di Milano, Italy.
Acta Obstet Gynecol Scand. 1988;67(7):631-7. doi: 10.3109/00016348809004277.
To investigate ultrastructural modifications in the endometrium of women receiving clomiphene citrate (CC) treatment, we performed endometrial biopsies in the preovulatory phase in 17 patients with anovulatory infertility and 16 normo-ovulating women with tubal or male sterility. Histology, scanning and transmission electron microscopy (SEM and TEM) revealed midproliferative phase aspects in 11.7% of the treated group and 6% of the controls, late proliferative aspects in 76.4% and 82%, and postovulation days 1-3 characteristics in 11.7% and 12% respectively. No significant differences were observed between the patients and controls; our data indicate that CC taken in a dose not exceeding 100 mg/day from day 3 of the cycle can induce endometrial maturation that is almost identical with that of a spontaneous preovulatory phase. This type of endometrium should therefore allow implantation of a fertilized egg and maintain unmodified the complex biohumoral relations with the embryo.
为研究接受枸橼酸氯米芬（CC）治疗的女性子宫内膜的超微结构改变，我们对17例无排卵性不孕症患者和16例输卵管性或男性不育的排卵正常女性在排卵前期进行了子宫内膜活检。组织学、扫描电镜和透射电镜（SEM和TEM）检查显示，治疗组中11.7%和对照组中6%呈现增殖中期表现，76.4%和82%呈现增殖后期表现，分别有11.7%和12%呈现排卵后第1 - 3天的特征。患者与对照组之间未观察到显著差异；我们的数据表明，从周期第3天开始以不超过100mg/天的剂量服用CC可诱导子宫内膜成熟，其与自发排卵前期的子宫内膜成熟几乎相同。因此，这种类型的子宫内膜应能允许受精卵着床，并维持与胚胎复杂的生物体液关系不变。
