Department of Hepatobiliary Surgery, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710061, China.
Department of Anesthesiology, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, 710061, China.
Curr Cancer Drug Targets. 2020;20(9):647-653. doi: 10.2174/1568009620666200601140639.
MUC15, a member of the mucin family, is a heavily glycosylated transmembrane protein with the primary functions of lubricating surfaces, establishing a selective molecular barrier at the epithelium and mediating signal transduction. Aberrant expression of MUC15 plays a crucial role in the progression of multiple diseases, including malignant tumors. MUC15 has been identified as a tumor suppressor, but current evidence indicate its function as an oncogene in different types of cancers. MUC15 has been shown to be involved in the development of cancer and influence cellular growth, adhesion, invasion, metastasis and immune immunomodulation. However, the precise role of MUC15 in tumour development has not been thoroughly clarified. Here, we systematically summarize the structure and function of MUC15 in cancer, and discuss its potential role in cancer treatment.
MUC15 是黏蛋白家族的成员，是一种高度糖基化的跨膜蛋白，主要功能包括润滑表面、在上皮处建立选择性分子屏障和介导信号转导。MUC15 的异常表达在多种疾病的进展中起着关键作用，包括恶性肿瘤。MUC15 已被确定为肿瘤抑制因子，但现有证据表明其在不同类型的癌症中作为癌基因发挥作用。MUC15 被证明参与癌症的发展，并影响细胞生长、黏附、侵袭、转移和免疫免疫调节。然而，MUC15 在肿瘤发展中的确切作用尚未得到彻底阐明。在这里，我们系统地总结了 MUC15 在癌症中的结构和功能，并讨论了其在癌症治疗中的潜在作用。
