Schembri Matthew, Sahu Jayanta, Aboumarzouk Omar, Pietropaolo Amelia, Somani Bhaskar K
University Hospital Southampton NHS Trust, Southampton, UK.
Zepler Institute for Photonics and Nanoelectrics, University of Southampton, Southampton, UK.
Turk J Urol. 2020 Nov;46(Supp. 1):S1-S10. doi: 10.5152/tud.2020.20093. Epub 2020 May 27.
Laser technology in urology is currently used for both stone lithotripsy and prostate enucleation. Thulium fiber laser (TFL) is a novel laser, with initial studies showing potential benefits over other lasers both in terms of its effectiveness and safety profile.
In the first part of this review, a descriptive analysis of the theoretical concepts behind TFL was performed. This part focused on the physics and laser parameters as applied to the clinical practice. These were interpreted in the context of other lasers, namely, the Holmium:YAG laser to highlight the theoretical advantages as well as potential pitfalls offered by the TFL. In the second part of the review, a narrative synthesis of in-vitro studies regarding TFL and its modifications is performed assessing stone-related parameters, namely, ablation rate, operative time retropulsion, and safety.
TFL achieved high ablation rates in most studies and performed better than Holmium:YAG laser across a range of different settings and ablation modes when the two lasers were compared. Moreover, its ability to use low pulse energy ensures minimal stone retropulsion with the retropulsion threshold estimated to be 2-4 times higher than that of Holmium:YAG laser. From a safety viewpoint, TFL poses no additional risks than other lasers, although it does potentially lead to slightly higher temperatures in the surrounding tissues during lithotripsy.
The unique properties of TFL have made it an attractive alternative to conventional laser techniques currently used in urology. Clinical studies are required before its application can become more widespread.
激光技术目前在泌尿外科中用于结石碎石术和前列腺剜除术。铥光纤激光(TFL)是一种新型激光,初步研究表明,在有效性和安全性方面,它比其他激光具有潜在优势。
在本综述的第一部分,对TFL背后的理论概念进行了描述性分析。这部分重点关注应用于临床实践的物理原理和激光参数。在其他激光(即钬激光:钇铝石榴石激光)的背景下对这些内容进行了解释,以突出TFL的理论优势以及潜在缺陷。在综述的第二部分,对关于TFL及其改进的体外研究进行了叙述性综合分析,评估与结石相关的参数,即消融率、手术时间、结石回退和安全性。
在大多数研究中,TFL实现了高消融率,并且在比较这两种激光时,在一系列不同的设置和消融模式下,其表现优于钬激光:钇铝石榴石激光。此外,其使用低脉冲能量的能力可确保结石回退最小化,据估计其回退阈值比钬激光:钇铝石榴石激光高2至4倍。从安全性角度来看,TFL与其他激光相比不会带来额外风险,尽管在碎石过程中它确实可能导致周围组织温度略高。
TFL的独特特性使其成为泌尿外科目前使用的传统激光技术的有吸引力的替代方案。在其应用更广泛之前,需要进行临床研究。