Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Nano Lett. 2020 Jul 8;20(7):4816-4822. doi: 10.1021/acs.nanolett.0c00648. Epub 2020 Jun 9.
On-demand delivery of substances has been demonstrated for various applications in the fields of chemistry and biomedical engineering. Single-pulse release profile has been shown previously for micro/nanoparticles in different form factors. However, to obtain a sustained release, a pulsatile release profile is needed. Here, we demonstrate such a release profile from polymer magnetic nanocomposite microspheres loaded with chemicals. By exciting the microactuators with AC magnetic fields, we could achieve up to 61% cumulative release over a five-day period. One of the main advantages of using a magnetic stimulus is that the properties of the environment (e.g., transparency, density, and depth) in which the particles are located do not affect the performance. The operating magnitude of the magnetic field used in this work is safe and does not interact with any nonmetallic materials. The proposed approach can potentially be used in microchemistry, drug delivery, lab-on-chip, and microrobots for drug delivery.
按需输送物质在化学和生物医学工程领域的各种应用中已有演示。先前已经展示了不同形态因子的微/纳米颗粒的单脉冲释放曲线。然而，为了获得持续释放，需要脉冲释放曲线。在这里，我们展示了负载有化学物质的聚合物磁性纳米复合材料微球的这种释放曲线。通过用交流磁场激励微致动器，我们可以在五天的时间内实现高达 61%的累积释放。使用磁场刺激的主要优点之一是，颗粒所在环境的特性（例如透明度、密度和深度）不会影响性能。本工作中使用的磁场工作幅度是安全的，并且不会与任何非金属材料相互作用。所提出的方法可能在微化学、药物输送、芯片实验室和用于药物输送的微机器人中得到应用。
