Fang Danruo, Jin Hansong, Huang Xiulin, Shi Yongxin, Liu Zeyu, Ben Suqin
Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Front Chem. 2021 Nov 8;9:789934. doi: 10.3389/fchem.2021.789934. eCollection 2021.
Non-small cell lung cancer (NSCLC) is considered to be a principal cause of cancer death across the world, and nanomedicine has provided promising alternatives for the treatment of NSCLC in recent years. Photothermal therapy (PTT) and chemodynamic therapy (CDT) have represented novel therapeutic modalities for cancer treatment with excellent performance. The purpose of this research was to evaluate the effects of PPy@FeO nanoparticles (NPs) on inhibiting growth and metastasis of NSCLC by combination of PTT and CDT. In this study, we synthesized PPy@FeO NPs through a very facile electrostatic absorption method. And we detected reactive oxygen species production, cell apoptosis, migration and protein expression in different groups of A549 cells and established xenograft models to evaluate the effects of PPy@FeO NPs for inhibiting the growth of NSCLC. The results showed that the PPy@FeO NPs had negligible cytotoxicity and could efficiently inhibit the cell growth and metastasis of NSCLC . In addition, the PPy@FeO NPs decreased tumor volume and growth and endowed their excellent MRI capability of observing the location and size of tumor. To sum up, our study displayed that the PPy@FeO NPs had significant synergistic effects of PTT and CDT, and had good biocompatibility and safety and . The PPy@FeO NPs may be an effective drug platform for the treatment of NSCLC.
非小细胞肺癌（NSCLC）被认为是全球癌症死亡的主要原因，近年来纳米医学为NSCLC的治疗提供了有前景的替代方案。光热疗法（PTT）和化学动力学疗法（CDT）代表了具有卓越性能的新型癌症治疗方式。本研究的目的是通过PTT和CDT联合评估聚吡咯@氧化亚铁纳米颗粒（NPs）对抑制NSCLC生长和转移的效果。在本研究中，我们通过一种非常简便的静电吸附方法合成了聚吡咯@氧化亚铁NPs。并且我们检测了不同组A549细胞中活性氧的产生、细胞凋亡、迁移及蛋白表达，并建立异种移植模型以评估聚吡咯@氧化亚铁NPs对抑制NSCLC生长的效果。结果表明，聚吡咯@氧化亚铁NPs具有可忽略不计的细胞毒性，并且能够有效抑制NSCLC的细胞生长和转移。此外，聚吡咯@氧化亚铁NPs减小了肿瘤体积和生长，并赋予其观察肿瘤位置和大小的出色磁共振成像能力。综上所述，我们的研究表明聚吡咯@氧化亚铁NPs具有PTT和CDT的显著协同作用，并且具有良好的生物相容性和安全性。聚吡咯@氧化亚铁NPs可能是一种治疗NSCLC的有效药物平台。
