Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China.
Curr Opin Chem Biol. 2020 Oct;58:20-27. doi: 10.1016/j.cbpa.2020.04.009. Epub 2020 May 29.
Carbohydrates play important roles in life science, but their synthesis is always hampered by their complicated chemical structures. Scientists have never stopped trying to solve the problem of glycan synthesis from various aspects. Here a brief overview of recent progress in glycan synthesis, including chemical approaches, chemoenzymatic approaches, and automated synthesis, will be discussed, focusing on the efficiency of new glycosylation methods, the stereoselectivity of coupled products, and their applications in the assembly of complex glycan chains.
碳水化合物在生命科学中扮演着重要的角色，但由于其复杂的化学结构，它们的合成一直受到阻碍。科学家们从未停止过从各个方面解决聚糖合成问题的努力。本文将简要综述聚糖合成的最新进展，包括化学方法、化学酶法和自动化合成，重点讨论新糖基化方法的效率、偶联产物的立体选择性及其在复杂糖链组装中的应用。
