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[呼吸道平滑肌细胞间连接的超微结构]

[Ultrastructure of intercellular contacts of smooth myocytes of the respiratory tract].

作者信息

Zashikhin A L

出版信息

Arkh Anat Gistol Embriol. 1988 Dec;95(12):49-54.

PMID:3248051
Abstract

By means of electron microscopy at various stages of pre- and postnatal ontogenesis in rats and mice intercellular connections of smooth myocytes, included into the bronchial wall composition, have been investigated. Interaction of the smooth myocytes is ensured with numerous and various types of specialized connections. Certain modifications of the nexus structure are described, they, perhaps, depend on the level of conformational changes of connexons--protein molecules, included into its composition and responsible for intensity of transfer of ions and metabolites. Between the smooth myocytes a contact, that was not previously described, is revealed. It is presented with a complex, formed by vesicular structures, concentrated in the area of oriented in parallel electron opaque membrane area of the interacting cells. Owing to the presence of punctate contacts, not only at early stages of development, but also in the definitive tissue, it is possible to consider them as an independent type of specialized connections, and not as immature forms of gap junctions. There are not any essential differences in the structure and distribution of the contacts during the time of the investigation.

摘要

通过电子显微镜,对大鼠和小鼠出生前及出生后不同发育阶段支气管壁中平滑肌细胞的细胞间连接进行了研究。平滑肌细胞之间的相互作用通过多种类型的特殊连接得以实现。文中描述了连接子结构的某些变化,这些变化可能取决于连接子(构成连接子且负责离子和代谢物转移强度的蛋白质分子)构象变化的程度。在平滑肌细胞之间发现了一种此前未被描述过的接触。它呈现为一种复合体,由囊泡结构形成,集中在相互作用细胞平行排列的电子不透明膜区域。由于点状接触不仅在发育早期存在,在成熟组织中也存在,因此可以将它们视为一种独立类型的特殊连接,而非间隙连接的不成熟形式。在研究期间,这些接触的结构和分布没有任何本质差异。

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