Block H U, Dunemann A, Niebisch M, Mest H J
Department of Pharmacology and Toxicology, Martin Luther University Halle-Wittenberg, GDR.
Biomed Biochim Acta. 1988;47(10-11):S141-4.
The 5,7-disubstituted s-triazolo(1,5-a)pyrimidines (TPs) trapidil and AR 12463 inhibited the thrombin-induced Thromboxane (TX) formation in washed human platelets in a concentration-dependent manner (Ic50:trapidil 410 mumol/l and AR 12463 9 mumol/l). The arachidonic acid (AA) liberation measured in parallel was unchanged or only reduced to a small extent. The present study shows that the inhibition of TX formation by trapidil and AR 12463 is independent of AA liberation of platelets.
5,7-二取代的s-三唑并(1,5-a)嘧啶（TPs）曲匹地尔和AR 12463以浓度依赖性方式抑制凝血酶诱导的洗涤人血小板中血栓素（TX）的形成（半数抑制浓度：曲匹地尔410μmol/L，AR 12463 9μmol/L）。同时测定的花生四烯酸（AA）释放未改变或仅略有降低。本研究表明，曲匹地尔和AR 12463对TX形成的抑制与血小板AA释放无关。
