Schimke E, Hildebrandt R, Grzeskowiak B
Centre of Diabetes and Metabolic Disorders, Berlin, GDR.
Biomed Biochim Acta. 1988;47(10-11):S274-7.
We investigated triglycerides, total cholesterol, HDL cholesterol, the fatty acid patterns of serum triglycerides, cholesterol esters and phospholipids in relation to the ADP induced platelet aggregation in 34 long-term insulin-dependent diabetic patients with an extremely long diabetes duration of about 40 years. The concentrations of triglycerides, total cholesterol and HDL cholesterol of the patients did not differ from those of an age-matched non-diabetic control group. In the insulin-dependent diabetics the percentages of arachidonic and eicosapentaenoic acid in both serum cholesterol esters and phospholipids were decreased in comparison with control subjects. No difference was observed with respect to the ADP induced platelet aggregation between long-term diabetics and controls. The findings demonstrate that type I diabetic patients with an extremely long duration of diabetes are not characterized by increased serum lipids or platelet aggregation, both being well known risk factors for macroangiopathy. However the decreased portions in eicosanoid synthesis precursors may indicate a disturbed fatty acid metabolism.
我们研究了34名糖尿病病程极长（约40年）的长期胰岛素依赖型糖尿病患者的甘油三酯、总胆固醇、高密度脂蛋白胆固醇、血清甘油三酯的脂肪酸模式、胆固醇酯和磷脂与ADP诱导的血小板聚集之间的关系。这些患者的甘油三酯、总胆固醇和高密度脂蛋白胆固醇浓度与年龄匹配的非糖尿病对照组相比无差异。与对照组相比，胰岛素依赖型糖尿病患者血清胆固醇酯和磷脂中花生四烯酸和二十碳五烯酸的百分比均降低。长期糖尿病患者和对照组在ADP诱导的血小板聚集方面未观察到差异。研究结果表明，糖尿病病程极长的I型糖尿病患者的特征并非血脂升高或血小板聚集增加，而这两者都是众所周知的大血管病变危险因素。然而，类花生酸合成前体比例的降低可能表明脂肪酸代谢紊乱。
