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复发性脑膜炎球菌性脑膜炎伴补体6(C6)缺乏:一例报告。

Recurrent meningococcal meningitis with complement 6 (C6) deficiency: A case report.

作者信息

Bae Ji Yun, Ham Ahrong, Choi Hee Jung, Kim Chung-Jong

机构信息

Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Republic of Korea.

出版信息

Medicine (Baltimore). 2020 May 22;99(21):e20362. doi: 10.1097/MD.0000000000020362.

Abstract

RATIONALE

Late complement deficiency increases susceptibility to meningococcal disease and recurrent infections. In Korea, 5 case reports have described meningococcal disease with complement deficiency. However, C6 deficiency has not been described previously.

PATIENT CONCERNS

A 21-year-old police trainee presented with recurrent meningococcal meningitis. He was housed in communal living quarters until 20 days before the initial symptom onset.

DIAGNOSIS

He was diagnosed with meningococcal meningitis with C6 deficiency.

INTERVENTIONS

He was treated with intravenous ceftriaxone. An additional dose of quadrivalent meningococcal conjugate vaccine was administered after discharge.

OUTCOMES

He was discharged without complications.

LESSONS

Screening for complement deficiency is necessary in patients with a history of recurrent meningococcal infections to provide appropriate care and prevent recurrent infections.

摘要

理论依据

晚期补体缺乏会增加患脑膜炎球菌病和反复感染的易感性。在韩国,已有5例病例报告描述了伴有补体缺乏的脑膜炎球菌病。然而,此前尚未有C6缺乏的相关描述。

患者情况

一名21岁的警察学员出现反复的脑膜炎球菌性脑膜炎。在最初症状出现前20天,他一直居住在集体宿舍。

诊断

他被诊断为患有C6缺乏的脑膜炎球菌性脑膜炎。

干预措施

他接受了静脉注射头孢曲松治疗。出院后额外接种了一剂四价脑膜炎球菌结合疫苗。

结果

他顺利出院,无并发症。

经验教训

对于有反复脑膜炎球菌感染病史的患者,进行补体缺乏筛查对于提供适当治疗和预防反复感染很有必要。

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Clinical implications of C6 complement component deficiency.C6 补体成分缺乏的临床意义。
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本文引用的文献

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Dissemination of Neisseria meningitidis.脑膜炎奈瑟菌的传播
N Engl J Med. 2011 Apr 21;364(16):1573-5. doi: 10.1056/NEJMcibr1101564.
10
Structure of the human C6 gene.人类C6基因的结构。
Biochemistry. 1993 Jun 22;32(24):6198-205. doi: 10.1021/bi00075a012.

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