Rosa Daniela Dornelles, Pasqualotto Alessandro C, de Quadros Maurício, Prezzi Sérgio Henrique
Internal Medicine Department, Nossa Senhora da Conceição Hospital, Porto Alegre, Rio Grande do Sul, Brazil.
Braz J Infect Dis. 2004 Aug;8(4):328-30. doi: 10.1590/s1413-86702004000400010. Epub 2004 Nov 19.
The authors report a case of deficiency of the eighth component of complement in a young adult with a history of three episodes of meningitis; one of them proved to be meningococcal. The literature was reviewed and meningitis due to Neisseria meningitidis strains causing disease in complement-deficient and complement-sufficient patients was demonstrated. Meningococcal disease may be the first manifestation of complement deficiency; screening for complement function must be considered for those with invasive meningococcal disease, with posterior evaluation of the components of the terminal pathway of complement.
作者报告了一例年轻成人补体第八成分缺乏的病例，该患者有三次脑膜炎发作史，其中一次经证实为脑膜炎球菌性脑膜炎。回顾了相关文献，并展示了在补体缺乏和补体充足的患者中由脑膜炎奈瑟菌菌株引起疾病的脑膜炎情况。脑膜炎球菌病可能是补体缺乏的首发表现；对于侵袭性脑膜炎球菌病患者，必须考虑进行补体功能筛查，并对补体终末途径的成分进行后续评估。
