Peng Wei, Zhao Ying, Wang Yang, Wang Jun, Hao Qinghong, Tu Yang, Zhu Tianmin
Acupuncture & Tuina College.
Rehabilitation and Health Preservation College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Medicine (Baltimore). 2020 May 22;99(21):e20453. doi: 10.1097/MD.0000000000020453.
Primary insomnia (PI) is a common disease affecting human health. As the side effects of drug therapy were revealed, people began to seek more safe and effective non-drug therapies. Cognitive behavioral therapy for insomnia (CBT-I) and acupuncture are 2 commonly used non-drug therapies. However, there are few comparative studies on the efficacy of these 2 therapies. Therefore, this study aims to compare the efficacy and safety of the 2 therapies through network meta-analysis.
We will search the following electronic bibliographic databases: PubMed, EMBASE, The Cochrane Library, Web of Science, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, Chongqing VIP database, and Wanfang database. Randomized controlled trials in which the intervention was acupuncture or CBT, and in which the control group was any of the above, western medicine or blank control, would be included. The primary outcome will be the changes of the Pittsburgh Sleep Quality Index, and the additional outcomes will include the changes in Insomnia Severity Index, quality of life, clinical effective rate and adverse events. Two independent authors will screen the literature in the above database, extract data and cross-check. Heterogeneity and inconsistencies are detected before using a network meta-analysis method based on frequency analysis. The risk of bias will be assessed in accordance with the Cochrane risk of bias tool, and the strength of the recommendations will be assessed by the Grading of Recommendations Assessment, Development and Evaluation.
This network meta-analysis will provide a reference for clinicians and PI patients to choose a more appropriate non-drug regimen among multiple kinds of acupuncture or CBT-I therapies. This review does not require ethical approval and will be reported in a peer-reviewed journal.
PROSPERO CRD42020155327.
原发性失眠（PI）是一种影响人类健康的常见疾病。随着药物治疗副作用的显现，人们开始寻求更安全有效的非药物治疗方法。失眠认知行为疗法（CBT-I）和针灸是两种常用的非药物治疗方法。然而，关于这两种疗法疗效的比较研究较少。因此，本研究旨在通过网络荟萃分析比较这两种疗法的疗效和安全性。
我们将检索以下电子文献数据库：PubMed、EMBASE、Cochrane图书馆、Web of Science、中国知网、中国生物医学文献数据库、重庆维普数据库和万方数据库。纳入干预措施为针灸或CBT，对照组为上述任何一种、西药或空白对照的随机对照试验。主要结局将是匹兹堡睡眠质量指数的变化，额外结局将包括失眠严重程度指数的变化、生活质量、临床有效率和不良事件。两名独立作者将筛选上述数据库中的文献，提取数据并交叉核对。在使用基于频率分析的网络荟萃分析方法之前，检测异质性和不一致性。将根据Cochrane偏倚风险工具评估偏倚风险，并通过推荐分级评估、制定和评价来评估推荐强度。
本网络荟萃分析将为临床医生和PI患者在多种针灸或CBT-I疗法中选择更合适的非药物治疗方案提供参考。本综述无需伦理批准，并将在同行评审期刊上发表。
PROSPERO CRD42020155327。
