Qiao Feng, Luo Peng, Liu Chun-Hui, Fu Kai, Zhao Yan-Bin
Department of Cardiothoracic Surgery.
Department of Health Management Medical Examination Center, First Affiliated Hospital of Jiamusi University, Jiamusi.
Medicine (Baltimore). 2020 May 29;99(22):e20314. doi: 10.1097/MD.0000000000020314.
Previous studies have reported that microRNA 21 (mRNA 21) has involved in the procedure of lung cancer (LC). However, its conclusions are still unclear. Thus, this study will try to elaborate the association between mRNA 21 expression in serum and LC.
The electronic databases of Cochrane Library, PubMed, EMBASE, Allied and Complementary Medicine Database, WANGFANG database, and China National Knowledge Infrastructure will be retrieved from the inception to the present. All electronic databases will be searched without limitations of language and geographical location. Case-controlled studies reporting the association between mRNA 21 expression in serum and LC will be included. In addition, we will also identify other literature sources to avoid missing potential studies. All study selection, information collection, and study quality assessment will be performed by 2 independent authors. RevMan V.5.3 software and Stata V.12.0 software will be used for data synthesis and analysis.
This study will summarize current evidence to investigate the association between mRNA 21 expression in serum and LC.
The findings of this study will present comprehensive evidence to determine whether mRNA 21 expression in serum is relevant with LC or not.
INPLASY202040055.
既往研究报道称，微小RNA 21（miR-21）参与了肺癌（LC）的发病过程。然而，其结论仍不明确。因此，本研究将试图阐明血清中miR-21表达与肺癌之间的关联。
检索Cochrane图书馆、PubMed、EMBASE、补充与替代医学数据库、万方数据库和中国知网等电子数据库，检索时间从建库至当前。所有电子数据库的检索均不受语言和地理位置限制。纳入报道血清中miR-21表达与肺癌之间关联的病例对照研究。此外，我们还将查找其他文献来源，以避免遗漏潜在的研究。所有研究的筛选、信息收集和研究质量评估将由两名独立作者进行。将使用RevMan V.5.3软件和Stata V.12.0软件进行数据合成和分析。
本研究将总结当前证据，以调查血清中miR-21表达与肺癌之间的关联。
本研究结果将提供全面证据，以确定血清中miR-21表达是否与肺癌相关。
INPLASY202040055。
