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母亲强化奶摄入量与极低出生体重儿体重增长模式的关系。

Role of the Proportional Intake of Fortified Mother's Own Milk in the Weight Gain Pattern of Their Very-Preterm-Born Infants.

机构信息

Department of Pediatrics, Rutgers Robert Wood Johnson Medical School, 89 French Street, New Brunswick, NJ 08901, USA.

出版信息

Nutrients. 2020 May 28;12(6):1571. doi: 10.3390/nu12061571.

Abstract

Breastfeeding has been recommended for preterm infants as the optimal diet from nutritional, gastrointestinal, immunological, and developmental perspectives. However, the relevance of differing intakes of fortified mother's own milk (MOM) on the growth of their preterm infants is a challenging question because of the potential risk of extrauterine growth impairment, apart from its essential role in the provision of biological and immunological factors, and the reduction of serious morbidities. We aimed to identify the weight gain pattern in very-preterm-born infants with respect to their proportional intake of fortified MOM. The daily and average weight gain, dietary volume, calories, and proportional intake of fortified MOM were studied in a cohort of 84 very-preterm-born infants during the first 2 weeks post initiation of full enteral feeds. Groups 1, 2, and 3 were comprised of infants with a proportional fortified MOM intake of 85% or more, 35% to 84.9%, and 0 to 34.9%, respectively. Data analysis included regression models and a group-based comparison of the number of infants with weight gain that would be considered minimally acceptable for normal intrauterine growth. The infants' weight gain was not found to be associated with the proportional intake of fortified MOM or other feeding parameters. Overall, the intergroup variability in the proportion of infants with weight gain less than the lower limit of normal fetal growth was insignificant. During the first 2 weeks post initiation of full enteral feeds, the weight gain pattern of the studied very-preterm-born infants was not significantly dependent on the proportional intake of fortified maternal milk.

摘要

母乳喂养一直被推荐作为早产儿的最佳饮食,从营养、胃肠道、免疫和发育的角度来看都是如此。然而,由于强化母亲自身奶(MOM)的摄入量不同可能会导致宫外生长发育受损,除了它在提供生物和免疫因素以及减少严重发病率方面的重要作用外,早产儿的生长情况也是一个具有挑战性的问题。我们旨在确定非常早产儿根据其强化 MOM 的比例摄入情况的体重增加模式。在开始完全肠内喂养后的前 2 周,我们研究了 84 名非常早产儿的日常和平均体重增加、饮食量、热量和强化 MOM 的比例摄入情况。第 1、2 和 3 组分别由摄入比例为 85%或更高、35%至 84.9%和 0 至 34.9%的强化 MOM 的婴儿组成。数据分析包括回归模型和对体重增加被认为是正常宫内生长最小可接受的婴儿数量的基于组的比较。婴儿的体重增加与强化 MOM 的比例摄入或其他喂养参数无关。总体而言,组间体重增加低于正常胎儿生长下限的婴儿比例的变异性无显著性差异。在开始完全肠内喂养后的前 2 周,研究中非常早产儿的体重增加模式与强化母乳的比例摄入没有显著关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99da/7352929/1401d3de1f58/nutrients-12-01571-g001.jpg

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