Ormerod L P
Chest Clinic, Blackburn Royal Infirmary.
Br J Dis Chest. 1988 Jul;82(3):274-81. doi: 10.1016/0007-0971(88)90068-x.
A retrospective radiographic comparison of two regimens, RHE2/RH10 (n = 32) and RHZ2/RH10 (n = 37), used in the treatment of tuberculous mediastinal lymphadenopathy is reported. The two groups did not differ in age, pretreatment or post-treatment values. The rate of improvement in serial radiographs was compared between the two groups, each patient acting as his own control. There was no difference in the incidence of initial gland enlargement at 1 month, but at 2 months RHZ2/RH10 had less enlargement (0.05 greater than P greater than 0.01). The rate of improvement was faster in the RHZ2/RH10 group from 2-7 months' treatment, being significantly better than RHE2/RH10 at 2 (P = 0.003), 5 (0.01 greater than P) and 7 months (0.02 greater than P). Pyrazinamide (25-40 mg/kg) appears to be superior to ethambutol 15 mg/kg for the initial 2 months of treatment of tuberculous mediastinal lymphadenopathy. The findings may be applicable to peripheral tuberculous lymphadenopathy.
报告了对用于治疗结核性纵隔淋巴结肿大的两种治疗方案RHE2/RH10（n = 32）和RHZ2/RH10（n = 37）进行的回顾性影像学比较。两组在年龄、治疗前或治疗后值方面没有差异。比较了两组连续X线片的改善率，每位患者作为自身对照。在1个月时初始腺体肿大的发生率没有差异，但在2个月时RHZ2/RH10组的肿大程度较轻（0.05＞P＞0.01）。在治疗2至7个月期间，RHZ2/RH10组的改善率更快，在2个月（P = 0.003）、5个月（0.01＞P）和7个月（0.02＞P）时明显优于RHE2/RH10组。对于结核性纵隔淋巴结肿大的初始2个月治疗，吡嗪酰胺（25 - 40mg/kg）似乎优于乙胺丁醇15mg/kg。这些发现可能适用于周围性结核性淋巴结肿大。
