Department of Intensive Care Unit, Sichuan Cancer Hospital & Institute, Chengdu, Sichuan, China.
Department of Thoracic Surgery, Sichuan Cancer Hospital & Institute, Chengdu, Sichuan, China.
Nutr Cancer. 2021;73(4):609-616. doi: 10.1080/01635581.2020.1769690. Epub 2020 Jun 1.
To evaluate early oral feeding (EOF) in short-term outcomes of patients with esophageal cancer after esophagectomy. 179 patients with esophageal cancer who underwent esophagectomy between January 2016 and February 2018 were enrolled for this study. 87 patients with EOF without nasogastric tube or nasogastric tube was removed within 24 h, were selected as the experimental group, whereas 92 patients who received nasojejunal tube feeding were set as the control group. All laboratory testing, clinical features, and hospitalization expenses were compared between the two groups. No statistical significance was observed between the two groups in hemoglobin, albumin, and prealbumin levels after esophagectomy. Notably, there was no significant difference in the incidence of severe pneumonia and anastomotic leakage between the two groups. Admittance period, postoperative defecation time, and medical expenses were significantly decreased among patients with EOF ( < 0.001). Multivariate Cox multiple-factor regression analysis revealed that there was no correlation between EOF and the risk of anastomotic leakage. EOF might not be a risk factor for increasing the incidence of severe pneumonia and anastomotic leakage in patients with esophageal cancer after esophagectomy, and it could reduce the hospitalization period as well as control medical expenses.
为了评估食管癌患者术后早期口服喂养（EOF）对短期结局的影响。本研究纳入了 179 例 2016 年 1 月至 2018 年 2 月期间接受食管癌切除术的患者。选择 87 例接受 EOF 治疗且未放置鼻胃管或在 24 小时内拔除鼻胃管的患者作为实验组，92 例接受鼻肠管喂养的患者作为对照组。比较两组患者的所有实验室检查、临床特征和住院费用。两组患者术后血红蛋白、白蛋白和前白蛋白水平无统计学差异。值得注意的是，两组患者严重肺炎和吻合口漏的发生率无显著差异。EOF 组的住院时间、术后排便时间和医疗费用明显降低（<0.001）。多因素 Cox 多因素回归分析显示，EOF 与吻合口漏的风险无关。EOF 可能不是增加食管癌患者术后严重肺炎和吻合口漏发生率的危险因素，它可以缩短住院时间并控制医疗费用。
