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ANGI-神经性厌食症遗传学倡议。

ANGI - Anorexia Nervosa Genetics Initiative.

机构信息

Center of Excellence for Eating Disorders, Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

出版信息

Twin Res Hum Genet. 2020 Apr;23(2):135-136. doi: 10.1017/thg.2020.24.

Abstract

Identification of genetic variants associated with eating disorders is underway. The Anorexia Nervosa Genetics Initiative, an initiative of the Klarman Family Foundation, has contributed to advancing the field, yielding a large-scale genome-wide association study published in Nature Genetics. Eight genetic variants significantly associated with anorexia nervosa were identified, along with patterns of genetic correlations that suggest both psychiatric and metabolic origins of this serious and life-threatening illness. This article details the role of Professor Nick Martin in contributing to this important collaboration.

摘要

正在进行与饮食失调相关的遗传变异的鉴定。Klarman 家族基金会的厌食症遗传学倡议为该领域的发展做出了贡献,其研究成果发表在《自然遗传学》上的一项大规模全基因组关联研究。研究确定了 8 个与神经性厌食症显著相关的遗传变异,以及遗传相关性模式,表明这种严重且危及生命的疾病既有精神方面的也有代谢方面的起源。本文详细介绍了尼克·马丁教授在促成这一重要合作中所发挥的作用。

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