Potashnik G, Ben-Adereth N, Lunenfeld B, Rofe C
Fertil Steril. 1977 Jun;28(6):650-4. doi: 10.1016/s0015-0282(16)42617-8.
An attempt has been made to assess the pituitary response to the nasal application of synthetic gonadotropin-releasing hormone (GnRH) in three oligospermic and two azoospermic men. Intranasal administration of 3 mg of GnRH in aqueous or natural plant gum solution produced a pituitary response pattern similar to that produced by the intramuscular injection of 100 microng, with respect to plasma concentrations of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). No technical difficulties or side effects were observed. GnRH in a nasal drop preparation seems to be effective in releasing LH and FSH in men. These findings may have a practical application in those cases where long-term therapy with the hormone is indicated.
已尝试评估合成促性腺激素释放激素（GnRH）经鼻腔给药对3例少精子症男性和2例无精子症男性垂体的反应。在水或天然植物胶溶液中经鼻给予3毫克GnRH，就黄体生成素（LH）和促卵泡激素（FSH）的血浆浓度而言，所产生的垂体反应模式与肌肉注射100微克所产生的模式相似。未观察到技术困难或副作用。滴鼻剂形式的GnRH似乎对男性释放LH和FSH有效。这些发现可能在需要长期使用该激素治疗的病例中有实际应用价值。
