Bain J, Moskowitz J P, Clapp J J
Arch Androl. 1978;1(2):147-52. doi: 10.3109/01485017808988331.
GnRH was administered to 34 men (8 normospermic, 8 moderately oligospermic, 10 severely oligospermic and 8 azoospermic) and the responsiveness of serum LH and FSH determined. For LH, basal levels were not different among each group, nor was there any difference in response to GnRH at any point in time after injection; however, there was a trend for the azoospermic group to respond more briskly. For FSH, basal levels also did not differ among the groups, but both the azoospermic and severely oligospermic groups showed a hyperresponsiveness that differed significantly from the response elicited by the normospermic group. It is concluded that oligo-azoospermia results from a pantesticular defect involving both seminiferous tubules and Leydig cells and that latent pituitary insufficiency is rarely a cause of subfertility in men.
对34名男性（8名精子正常、8名中度少精子症、10名重度少精子症和8名无精子症患者）给予促性腺激素释放激素（GnRH），并测定血清促黄体生成素（LH）和促卵泡生成素（FSH）的反应性。对于LH，各组之间的基础水平无差异，注射后任何时间点对GnRH的反应也无差异；然而，无精子症组有反应更活跃的趋势。对于FSH，各组之间的基础水平也无差异，但无精子症组和重度少精子症组均表现出高反应性，这与精子正常组引起的反应有显著差异。结论是，少精子症和无精子症是由涉及生精小管和 Leydig 细胞的全睾丸缺陷引起的，而潜在的垂体功能不全很少是男性生育力低下的原因。
