Borges P C, Coimbra N C, Brandão M L
Departamento de Ciências Fisiológicas, Universidade Federal do Espírito Santo, Vitória, Brasil.
Braz J Med Biol Res. 1988;21(5):1027-31.
Electrical stimulation of the dorsal periaqueductal gray (DPAG) elicits autonomic responses similar to those following peripheral pain stimulation. The present study analyzes the effects of morphine and midazolan applied to the same DPAG site on the autonomic responses induced by both types of stimulation. Both drugs attenuated the increase in heart rate and blood pressure induced by DPAG stimulation while attenuating only the increase in heart rate induced by pain stimulation. These results suggest that the neural substrates of the autonomic expression of the DPAG and pain stimulation are different although they may partially overlap.
对中脑导水管周围灰质背侧（DPAG）进行电刺激会引发与外周疼痛刺激后相似的自主反应。本研究分析了将吗啡和咪达唑仑应用于同一DPAG部位对这两种刺激所诱导的自主反应的影响。两种药物均减弱了DPAG刺激所诱导的心率和血压升高，而仅减弱了疼痛刺激所诱导的心率升高。这些结果表明，DPAG自主表达和疼痛刺激的神经基质虽可能部分重叠，但有所不同。
